Biomanufacturing organized collagen-based microfibers as a Tissue ENgineered Device (TEND) for tendon regeneration

Approximately 800, 000 surgical repairs are performed annually in the U.S. for debilitating injuries to ligaments and tendons of the foot, ankle, knee, wrist, elbow and shoulder, presenting a significant healthcare burden. To overcome current treatment shortcomings and advance the treatment of tendo...

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Published inBiomedical materials (Bristol) Vol. 16; no. 2; p. 025025
Main Authors Maghdouri-White, Yas, Sori, Nardos, Petrova, Stella, Wriggers, Hilary, Kemper, Nathan, Dasgupta, Amrita, Coughenour, Kelly, Polk, Seth, Thayer, Nick, Mario, Rodriguez Dvm, Simon Dpm, Bill, Bulysheva, Anna, Bonner, Kevin, Arnoczky Dvm, Steven, Adams Md, Samuel, Francis, Michael P
Format Journal Article
LanguageEnglish
Published England 01.03.2021
Subjects
Achilles Tendon - pathology
Achilles Tendon - surgery
Adsorption
Animals
Bone Marrow Cells - cytology
Cell Differentiation
Cell Proliferation
Cell Survival
Collagen Type I - metabolism
Connective Tissue
Female
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Male
Platelet-Rich Plasma - metabolism
Polyesters - chemistry
Porosity
Rabbits
Rats
Regeneration
Spectroscopy, Fourier Transform Infrared
Stem Cells - cytology
Stress, Mechanical
Tendon Injuries - surgery
Tendons - cytology
Thermogravimetry
Tissue Engineering - instrumentation
Tissue Engineering - methods
Up-Regulation
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Abstract Approximately 800, 000 surgical repairs are performed annually in the U.S. for debilitating injuries to ligaments and tendons of the foot, ankle, knee, wrist, elbow and shoulder, presenting a significant healthcare burden. To overcome current treatment shortcomings and advance the treatment of tendon and ligament injuries, we have developed a novel electrospun Tissue ENgineered Device (TEND), comprised of type I collagen and poly(D,L-lactide) (PDLLA) solubilized in a benign solvent, dimethyl sulfoxide (DMSO). TEND fiber alignment, diameter and porosity were engineered to enhance cell infiltration leading to promote tissue integration and functional remodeling while providing biomechanical stability. TEND rapidly adsorbs blood and platelet-rich-plasma (PRP), and gradually releases growth factors over two weeks. TEND further supported cellular alignment and upregulation of tenogenic genes from clinically relevant human stem cells within three days of culture. TEND implanted in a rabbit Achilles tendon injury model showed new in situ tissue generation, maturation, and remodeling of dense, regularly oriented connective tissue in vivo. In all, TEND's organized microfibers, biological fluid and cell compatibility, strength and biocompatiblility make significant progress towards clinically translating electrospun collagen-based medical devices for improving the clinical outcomes of tendon injuries.
AbstractList Approximately 800, 000 surgical repairs are performed annually in the U.S. for debilitating injuries to ligaments and tendons of the foot, ankle, knee, wrist, elbow and shoulder, presenting a significant healthcare burden. To overcome current treatment shortcomings and advance the treatment of tendon and ligament injuries, we have developed a novel electrospun Tissue ENgineered Device (TEND), comprised of type I collagen and poly(D,L-lactide) (PDLLA) solubilized in a benign solvent, dimethyl sulfoxide (DMSO). TEND fiber alignment, diameter and porosity were engineered to enhance cell infiltration leading to promote tissue integration and functional remodeling while providing biomechanical stability. TEND rapidly adsorbs blood and platelet-rich-plasma (PRP), and gradually releases growth factors over two weeks. TEND further supported cellular alignment and upregulation of tenogenic genes from clinically relevant human stem cells within three days of culture. TEND implanted in a rabbit Achilles tendon injury model showed new in situ tissue generation, maturation, and remodeling of dense, regularly oriented connective tissue in vivo. In all, TEND's organized microfibers, biological fluid and cell compatibility, strength and biocompatiblility make significant progress towards clinically translating electrospun collagen-based medical devices for improving the clinical outcomes of tendon injuries.
Approximately 800, 000 surgical repairs are performed annually in the U.S. for debilitating injuries to ligaments and tendons of the foot, ankle, knee, wrist, elbow and shoulder, presenting a significant healthcare burden. To overcome current treatment shortcomings and advance the treatment of tendon and ligament injuries, we have developed a novel electrospun T issue EN gineered D evice ( TEND ), comprised of type I collagen and poly(D,L-lactide) (PDLLA) solubilized in a benign solvent, dimethyl sulfoxide (DMSO). TEND fiber alignment, diameter and porosity were engineered to enhance cell infiltration leading to promote tissue integration and functional remodeling while providing biomechanical stability. TEND rapidly adsorbs blood and platelet-rich-plasma (PRP), and gradually releases growth factors over two weeks. TEND further supported cellular alignment and upregulation of tenogenic genes from clinically relevant human stem cells within three days of culture. TEND implanted in a rabbit Achilles tendon injury model showed new in situ tissue generation, maturation, and remodeling of dense, regularly oriented connective tissue in vivo . In all, TEND’s organized microfibers, biological fluid and cell compatibility, strength and biocompatiblility make significant progress towards clinically translating electrospun collagen-based medical devices for improving the clinical outcomes of tendon injuries.
Author Kemper, Nathan
Polk, Seth
Coughenour, Kelly
Wriggers, Hilary
Arnoczky Dvm, Steven
Thayer, Nick
Adams Md, Samuel
Bulysheva, Anna
Maghdouri-White, Yas
Petrova, Stella
Francis, Michael P
Dasgupta, Amrita
Bonner, Kevin
Sori, Nardos
Simon Dpm, Bill
Mario, Rodriguez Dvm
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  organization: Eastern Virginia Medical School, Norfolk, VA 23507, United States of America
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Snippet Approximately 800, 000 surgical repairs are performed annually in the U.S. for debilitating injuries to ligaments and tendons of the foot, ankle, knee, wrist,...
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pubmed
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StartPage 025025
SubjectTerms Achilles Tendon - pathology
Achilles Tendon - surgery
Adsorption
Animals
Bone Marrow Cells - cytology
Cell Differentiation
Cell Proliferation
Cell Survival
Collagen Type I - metabolism
Connective Tissue
Female
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Male
Platelet-Rich Plasma - metabolism
Polyesters - chemistry
Porosity
Rabbits
Rats
Regeneration
Spectroscopy, Fourier Transform Infrared
Stem Cells - cytology
Stress, Mechanical
Tendon Injuries - surgery
Tendons - cytology
Thermogravimetry
Tissue Engineering - instrumentation
Tissue Engineering - methods
Up-Regulation
Title Biomanufacturing organized collagen-based microfibers as a Tissue ENgineered Device (TEND) for tendon regeneration
URI https://www.ncbi.nlm.nih.gov/pubmed/32927444
https://search.proquest.com/docview/2442845167
Volume 16
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