Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

• Published in: Antioxidants & redox signaling Vol. 13; no. 11; p. 1713
• Main Authors: Hayes, John D, McMahon, Michael, Chowdhry, Sudhir, Dinkova-Kostova, Albena T
• Format: Journal Article
• Language: English
• Published: United States 01.12.2010
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Anticarcinogenic Agents - metabolism; Anticarcinogenic Agents - therapeutic use; Antioxidants - metabolism; Antioxidants - therapeutic use; Carrier Proteins - metabolism; Cell Proliferation - drug effects; Cullin Proteins - metabolism; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Kelch-Like ECH-Associated Protein 1; Neoplasms - metabolism; Neoplasms - prevention & control; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Response Elements - drug effects; Signal Transduction - drug effects; Trans-Activators - chemistry; Trans-Activators - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Vesicular Transport Proteins - genetics; Vesicular Transport Proteins - metabolism

The cap'n'collar (CNC) bZIP transcription factor Nrf2 controls expression of genes for antioxidant enzymes, metal-binding proteins, drug-metabolising enzymes, drug transporters, and molecular chaperones. Many chemicals that protect against carcinogenesis induce Nrf2-target genes. These com...