Molecular characterization of the glutathione peroxidase gene of the human malaria parasite Plasmodium falciparum

• Published in: Molecular and biochemical parasitology Vol. 78; no. 1-2; pp. 237 - 248
• Main Authors: Gamain, Benoît, Langsley, Gordon, Fourmaux, Marie N., Touzel, Jean P., Camus, Daniel, Dive, Daniel, Slomianny, Christian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.1996; Elsevier
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Binding Sites - genetics; Chemical and Process Engineering; DNA, Protozoan - genetics; Engineering Sciences; Food engineering; Gene; Genes, Protozoan; Glutathione peroxidase; Glutathione Peroxidase - chemistry; Glutathione Peroxidase - genetics; Glutathione Peroxidase - metabolism; Humans; Introns; Life Sciences; Malaria; Molecular Sequence Data; Molecular Structure; Molecular Weight; Nucleic Acid Conformation; Phylogenetic tree; Phylogeny; Plasmodium falciparum; Plasmodium falciparum - enzymology; Plasmodium falciparum - genetics; Polymerase Chain Reaction; RNA, Protozoan - chemistry; RNA, Protozoan - genetics; Selenium; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Species Specificity; Glutathione peroxidase; PhGPx; Plasmodium falciparum; Malaria; Gene; Phylogenetic tree; ROS; SOD; Selenium; GPx; PCR; PfGPx; GLUTATHIONE PEROXIDASE; MALARIA

In this paper we report the isolation and the characterization of a gene encoding the antioxidant enzyme glutathione peroxidase from the human malaria parasite Plasmodium falciparum. This gene contains two introns of 208 and 168 bp and is present in a single copy on chromosome 13. The open reading f...