Identification and signaling characterization of four urotensin II receptor subtypes in the western clawed frog, Xenopus tropicalis

• Published in: General and comparative endocrinology Vol. 299; p. 113586
• Main Authors: Konno, Norifumi, Takano, Moe, Miura, Koichi, Miyazato, Mikiya, Nakamachi, Tomoya, Matsuda, Kouhei, Kaiya, Hiroyuki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2020
• Subjects: Animals; Anura; Gene Expression Regulation - genetics; Signal Transduction; Signaling pathway; Urotensin II; Urotensin II receptor subtypes; Urotensins - metabolism; Xenopus tropicalis; Urotensin II; Signaling pathway; Urotensin II receptor subtypes; Xenopus tropicalis

•Four functional UTR (UTR1, UTR3, UTR4, and UTR5) subtypes are present in X. tropicalis.•UTR1 and UTR5 are most likely linked to PLC/PKC and GEF-H1/RhoA/ROCK/MLC signaling.•UTR3 and UTR4 are likely linked to GEF-H1/RhoA/ROCK/MLC signaling via the G12/13 protein.•Similarity between Xenopus UTR1 and U...