A novel tilapia prolactin receptor is functionally distinct from its paralog

• Published in: Journal of experimental biology Vol. 212; no. Pt 13; pp. 2007 - 2015
• Main Authors: Fiol, Diego F, Sanmarti, Enio, Sacchi, Romina, Kültz, Dietmar
• Format: Journal Article
• Language: English
• Published: England 01.07.2009
• Subjects: Alternative Splicing; Animals; Cell Line; Cloning, Molecular; Female; Fish Proteins - chemistry; Fish Proteins - genetics; Fish Proteins - physiology; Humans; Male; Osmotic Pressure; Receptors, Prolactin - chemistry; Receptors, Prolactin - genetics; Receptors, Prolactin - physiology; RNA, Messenger - metabolism; Signal Transduction; Tilapia - metabolism

A novel tilapia prolactin (PRL) receptor (OmPRLR2) was identified based on its induction during hyperosmotic stress. OmPRLR2 protein shows 28% identity to tilapia OmPRLR1 and 26% identity to human PRLR. Comparison of OmPRLR1 and OmPRLR2 revealed conserved features of cytokine class I receptors (CKR1...