Brain and platelet serotonin transporter in humans—correlation between [ 123I]-ADAM SPECT and serotonergic measurements in platelets

• Published in: Neuroscience letters Vol. 406; no. 3; pp. 153 - 158
• Main Authors: Uebelhack, Ralf, Franke, Leonora, Herold, Nathalie, Plotkin, Michael, Amthauer, Holger, Felix, Roland
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 09.10.2006; Elsevier
• Subjects: [ 125I]-ADAM; Adult; Biological and medical sciences; Blood platelets; Blood Platelets - diagnostic imaging; Blood Platelets - metabolism; Brain - diagnostic imaging; Brain - metabolism; Cinanserin - analogs & derivatives; Cinanserin - metabolism; Depression - blood; Depression - diagnostic imaging; Female; Fundamental and applied biological sciences. Psychology; Humans; Iodine Radioisotopes - metabolism; Male; Midbrain; Middle Aged; Psychotic Disorders - blood; Psychotic Disorders - diagnostic imaging; Radiopharmaceuticals - metabolism; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin transporter; Sex Factors; SPECT; Tomography, Emission-Computed, Single-Photon - methods; Vertebrates: nervous system and sense organs; [ 125I]-ADAM; Midbrain; Serotonin transporter; Blood platelets; SPECT; Human; Platelet; Central nervous system; [125I]-ADAM; Photon; Encephalon; Emission tomography

Blood platelets are thought to be a useful peripheral model for investigating the central serotoninergic mechanisms associated with the serotonin transporter (SERT). On the other hand, an in vivo investigation of SERT in the human brain has been made possible by the development of several promising...