The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions

• Published in: Experimental and molecular pathology Vol. 127; p. 104787
• Main Authors: Khezri, Mohammad Rafi, Jafari, Reza, Yousefi, Keyvan, Zolbanin, Naime Majidi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2022
• Subjects: Angiogenesis; Apoptosis; Cancer; PI3K/AKT; Angiogenesis; Apoptosis; Cancer; PI3K/AKT

The human body consists of countless cells with the possibility of excessive and uncontrolled proliferation under certain dysregulated circumstances that could cause abnormal states such as cancer. Phosphatidylinositol 3 kinase (PI3K) and its downstream target, Protein kinase B or AKT, play a critic...