Effect of Food on the Pharmacokinetics of Senaparib (IMP4297) in Healthy Chinese Subjects

• Published in: Clinical drug investigation Vol. 42; no. 11; pp. 1009 - 1016
• Main Authors: Meng, Xianmin, Lin, Xiaoyan, Jiang, Rongrong, Lu, Yan, Zeng, Liyan, Cao, Ming, Zhang, Jianliang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2022; Springer Nature B.V
• Subjects: Adenosine diphosphate; Administration, Oral; Apoptosis; Area Under Curve; Bioavailability; Biological Availability; China; Clinical medicine; Cross-Over Studies; DNA damage; Drug dosages; Food; Food-Drug Interactions; Health care; Healthy Volunteers; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; NCT; NCT04057729; Oral administration; Original; Original Research Article; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Plasma; Public health; China

Background and Objectives Data on the effect of food on the pharmacokinetics of senaparib (previously IMP4297), an oral poly (adenosine diphosphate-ribose) polymerase inhibitor, are limited. This study was conducted to evaluate the effect of food on the pharmacokinetics of senaparib in healthy Chine...