ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway

• Published in: Experimental and molecular pathology Vol. 113; p. 104350
• Main Authors: Ye, Rensong, Liu, Zhenwei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.04.2020
• Subjects: ACE/Ang II/AT1 axis; ACE2/Ang-(1–7)/mas axis; Acute lung injury; Angiotensin converting enzyme 2; Lipopolysaccharide; LPS-TLR4 pathway; Renin-angiotensin systems; Acute lung injury; Angiotensin converting enzyme 2; LPS-TLR4 pathway; Lipopolysaccharide; Renin-angiotensin systems; ACE2/Ang-(1–7)/mas axis; ACE/Ang II/AT1 axis

This study aimed to investigate the protective effect of angiotensin converting enzyme 2 (ACE2) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). After generating ALI mouse models by injecting LPS, the levels of ACE2, inflammatory factors, and downstream proteins of the LPS-TLR4 pathway w...