Brain connections derived from diffusion MRI tractography can be highly anatomically accurate—if we know where white matter pathways start, where they end, and where they do not go

• Published in: Brain structure & function Vol. 225; no. 8; pp. 2387 - 2402
• Main Authors: Schilling, Kurt G., Petit, Laurent, Rheault, Francois, Remedios, Samuel, Pierpaoli, Carlo, Anderson, Adam W., Landman, Bennett A., Descoteaux, Maxime
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2020; Springer Verlag
• Subjects: Biomedical and Life Sciences; Biomedicine; Cell Biology; Cognitive science; Neurology; Neuroscience; Neurosciences; Original Article; Validation; Diffusion MRI; White matter; Tractography; Tracer; white matter; tractography; tracer; validation

MR Tractography, which is based on MRI measures of water diffusivity, is currently the only method available for noninvasive reconstruction of fiber pathways in the brain. However, it has several fundamental limitations that call into question its accuracy in many applications. Therefore, there has...