Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration

• Published in: Brain research Vol. 1024; no. 1; pp. 137 - 145
• Main Authors: Álvarez-López, Carmen, Cernuda-Cernuda, Rafael, Alcorta, Esther, Álvarez-Viejo, María, Manuel García-Fernández, José
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 22.10.2004; Amsterdam Elsevier; New York, NY
• Subjects: Animals; Biological and medical sciences; Circadian rhythm; Circadian Rhythm - physiology; Clock; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; Darkness; Female; Male; Medical sciences; Mice; Mice, Inbred C3H; Mice, Transgenic; Ophthalmology; p-CREB; Phosphorylation; Photic Stimulation - methods; Retinal degeneration; Retinal Degeneration - genetics; Retinal Degeneration - metabolism; Retinopathies; SCN; Suprachiasmatic Nucleus - metabolism; Retinal degeneration; p-CREB; Circadian rhythm; Neural basis of behavior; Clock; SCN; Suprachiasmatic nucleus; Retinopathy; Rodentia; Retina; Eye disease; Vertebrata; Mammalia; Mouse; Animal; Degeneration; Transcription factor CREB

The effect of cone- and rod-cell loss on the activation of transcription factor CREB (by phosphorilation at Ser 133) was examined in the pacemaker of mammals, the suprachiasmatic nucleus (SCN). For this purpose, brain sections of rd/rd and wild-type C3H mice were immunolabelled with a polyclonal ant...