Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

• Published in: Biotechnology and bioengineering Vol. 117; no. 4; pp. 1187 - 1203
• Main Authors: Henry, Matthew N., MacDonald, Michael A., Orellana, Camila A., Gray, Peter P., Gillard, Marianne, Baker, Kym, Nielsen, Lars K., Marcellin, Esteban, Mahler, Stephen, Martínez, Verónica S.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2020
• Subjects: Animals; Apoptosis; Biological Products - metabolism; biopharmaceutical production; Biopharmaceuticals; Biotechnology; Cell culture; Cell Culture Techniques; Cell death; Cell Engineering; CHO cell line engineering; CHO Cells; Cricetinae; Cricetulus; Genetic engineering; programmed cell death; Substrates; Toxicity; CHO cell line engineering; apoptosis; programmed cell death; biopharmaceutical production

Chinese hamster ovary (CHO) cells are the predominant host cell line for the production of biopharmaceuticals, a growing industry currently worth more than $188 billion USD in global sales. CHO cells undergo programmed cell death (apoptosis) following different stresses encountered in cell culture,...