Synthesis and antioxidant activity evaluation of novel broom and cotton fibers derivatives

• Published in: Journal of applied polymer science Vol. 114; no. 5; pp. 3177 - 3183
• Main Authors: Trombino, Sonia, Cassano, Roberta, Ferrarelli, Teresa, Cilea, Alessia, Muzzalupo, Rita, Cione, Erika, Nevio, Picci
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2009; Wiley
• Subjects: antioxidants; Applied sciences; Biological and medical sciences; biomaterials; biomedical and packaging areas; Exact sciences and technology; fibers; Fibers and threads; Forms of application and semi-finished materials; General pharmacology; infrared spectroscopy; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymer industry, paints, wood; Technology of polymers; Reaction inhibitor; Biological properties; Lipoic acid; fibers; antioxidants; Plant fiber; Lipids; α-Tocopherol; Additive; Dicotyledones; Natural fiber; Angiospermae; Reaction inhibition; Biocompatibility; Biomaterial; biomaterials; Cotton fiber; Peroxidation; infrared spectroscopy; Microfibril; Antioxidant; Experimental study; Ferulic acid; biomedical and packaging areas; Chemical modification; Leguminosae; Stabilizer agent; Cytisus; Preparation; Cellulose derivatives; Phenols; Spermatophyta
• ISSN: 0021-8995; 1097-4628; 1097-4628
• DOI: 10.1002/app.30928

Novel antioxidant biopolymers composed by broom or cotton fibers, and trans-ferulic acid, α-lipoic acid, and α-tocopherol, were prepared. The acids were directly linked to fibers microfibrils hydroxylic groups using N,N-dimethylacetamide/lithium chloride (DMAc/LiCl) as solvent with dicyclohexylcarbodiimide (DCC) and N,N-dimethylaminopyridine (DMAP). Broom or cotton tocopherulate were prepared in the same conditions by using carboxylated fibers. Ester linkages were confirmed by using Fourier transformed infrared spectroscopy; biopolymers substitution degrees (DS) were determined by volumetric analysis. Antioxidant activity in inhibiting lipid peroxidation, in rat-liver microsomal membranes, induced in vitro by two different sources of free radicals, 2,2'-azobis (2-amidinopropane) (AAPH) and tert-butyl hydroperoxide (tert-BOOH), was evaluated. Finally, biocompatibility of these biomaterials was also tested by controlling glutathione-S-transferase (GST) basal concentrations. Our results strongly suggested that the better derivatives were the ferulate ones. However, all obtained biomaterials, showing excellent antioxidant properties and biocompatibility, could be successfully applied in biomedical and in packaging areas.