Pathological and molecular mechanisms of prostate carcinogenesis: Implications for diagnosis, detection, prevention, and treatment

• Published in: Journal of cellular biochemistry Vol. 91; no. 3; pp. 459 - 477
• Main Authors: De Marzo, Angelo M., DeWeese, Theodore L., Platz, Elizabeth A., Meeker, Alan K., Nakayama, Masashi, Epstein, Jonathan I., Isaacs, William B., Nelson, William G.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.02.2004
• Subjects: Atrophy - physiopathology; benign prostatic hyperplasia; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Homeodomain Proteins - genetics; Humans; inflammation; Inflammation - physiopathology; Male; Phosphoproteins - genetics; Phosphoric Monoester Hydrolases - genetics; prostate cancer; prostateatrophy; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Prostatic Neoplasms - therapy; prostatitis; Proteins - genetics; PTEN Phosphohydrolase; Racemases and Epimerases - genetics; Receptors, Androgen - genetics; Serine Endopeptidases - genetics; Signal Transduction; Telomere - genetics; Telomere - physiology; Trans-Activators - genetics; Transcription Factors - genetics; Tumor Suppressor Proteins - genetics
• ISSN: 0730-2312; 1097-4644
• DOI: 10.1002/jcb.10747

Prostate cancer is an increasing threat throughout the world. As a result of a demographic shift in population, the number of men at risk for developing prostate cancer is growing rapidly. For 2002, an estimated 189,000 prostate cancer cases were diagnosed in the U.S., accompanied by an estimated 30...