Metabolic, Cardiovascular, and Cerebrovascular Outcomes in Growth Hormone-Deficient Subjects with Previous Cushing’s Disease or Non-Functioning Pituitary Adenoma

• Published in: The journal of clinical endocrinology and metabolism Vol. 95; no. 2; pp. 630 - 638
• Main Authors: Webb, Susan M., Mo, Daojun, Lamberts, Steven W. J., Melmed, Shlomo, Cavagnini, Francesco, Pecori Giraldi, Francesca, Strasburger, Christian J., Zimmermann, Alan G., Woodmansee, Whitney W.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.02.2010; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adenoma; Adenoma - complications; Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adrenocorticotropic hormone; Adult; Aged; Biological and medical sciences; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cerebrovascular disease; Cerebrovascular diseases; Cerebrovascular Disorders - epidemiology; Diabetes; Diabetes mellitus; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Growth hormones; Human Growth Hormone - deficiency; Humans; Male; Medical sciences; Metabolic syndrome; Metabolic Syndrome - epidemiology; Middle Aged; Nervous system diseases; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pituitary; Pituitary ACTH Hypersecretion - complications; Pituitary Neoplasms - complications; Prevalence; Sex differences; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Endocrinopathy; Human; Obesity; Prognosis; Adrenal cortex diseases; Nutrition; Deficiency; Nutrition disorder; Cushing syndrome; Metabolic diseases; Cardiovascular disease; Hyperadrenocorticism; Metabolism; Somatotropin; Adenohypophyseal hormone; Adrenal gland diseases; Pituitary diseases; Pituitary adenoma; Endocrinology; Nutritional status

Context: Previous exposure to hypercortisolism due to Cushing’s disease (CD) may adversely affect long-term metabolic and cardiovascular outcomes. In particular, metabolic and cardiovascular outcomes of patients with previous CD who require GH replacement have not been fully established. Objective:...