Noninvasive Pulse Waveform Analysis in Clinical Trials: Similarity of Two Methods for Calculating Aortic Systolic Pressure

• Published in: American journal of hypertension Vol. 20; no. 8; pp. 917 - 922
• Main Authors: Adji, Audrey, Hirata, Kozo, Hoegler, Sonja, O’Rourke, Michael F.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2007; Oxford University Press; Elsevier Science
• Subjects: Administration, Oral; Aged; Antihypertensive Agents - administration & dosage; Aorta - physiopathology; Aortic systolic pressure; Arterial hypertension. Arterial hypotension; Atenolol - administration & dosage; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Blood Pressure - physiology; Blood Pressure Determination - methods; Cardiology. Vascular system; Cardiovascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Coronary Disease - drug therapy; Coronary Disease - physiopathology; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; generalized transfer-function technique; Humans; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Prognosis; Radial Artery - physiopathology; radial pressure waveform; Ramipril - administration & dosage; Risk Factors; Systole; radial pressure waveform; Aortic systolic pressure; generalized transfer-function technique; Waveform; Hypertension; Systolic pressure; Aorta; Cardiovascular disease

Concerns persist about the validity of generalized transfer function-derived, aortic blood-pressure measurements during the administration of vasoactive agents in clinical trials. Hence, we compared this transfer-function method with another, which estimates aortic systolic pressure directly from th...