Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry

• Published in: Biomedical chromatography Vol. 26; no. 6; pp. 754 - 760
• Main Authors: Tashiro, Masaki, Naito, Takafumi, Kagawa, Yoshiyuki, Kawakami, Junichi
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.06.2012
• Subjects: cancer patient; Chromatography, Liquid - methods; Drug Stability; Humans; LC-MS/MS; metabolite; Neoplasms - chemistry; Neoplasms - metabolism; plasma; prochlorperazine; Prochlorperazine - analogs & derivatives; Prochlorperazine - blood; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry - methods

ABSTRACT Oral prochlorperazine (PCZ), an antiemetic, undergoes extensive first‐pass metabolism. The study developed a simultaneous analytical method for PCZ and its major metabolites, prochlorperazine sulfoxide (PCZSO), N‐demethylprochlorperazine (NDPCZ) and 7‐hydroxyprochlorperazine (PCZOH), in hum...