Dynamic estimation of the myocardial oxygen extraction ratio during dipyridamole stress by MRI: A preliminary study in canines

• Published in: Magnetic resonance in medicine Vol. 51; no. 4; pp. 718 - 726
• Main Authors: Zheng, Jie, Wang, Jinghua, Nolte, Mark, Li, Debiao, Gropler, Robert J., Woodard, Pamela K.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2004
• Subjects: Animals; Blood Volume - physiology; Coronary Circulation - drug effects; Coronary Vessels; Dipyridamole; Dogs; Feasibility Studies; Image Enhancement - methods; Infusions, Intravenous; Magnetic Resonance Imaging, Cine - methods; myocardial perfusion; Myocardium - metabolism; Oxygen - blood; Oxygen Consumption - physiology; oxygen extraction; vasodilation; Vasodilator Agents

The myocardial oxygen extraction fraction (OEF) reflects the balance between myocardial oxygen supply and demand. The feasibility of quantifying myocardial OEF was demonstrated with MRI during pharmacologic vasodilation in dogs. Dipyridamole was infused intravenously to increase blood flow and chang...