Genistein Represses HOTAIR/Chromatin Remodeling Pathways to Suppress Kidney Cancer

• Published in: Cellular physiology and biochemistry Vol. 54; no. 1; pp. 53 - 70
• Main Authors: Imai-Sumida, Mitsuho, Dasgupta, Pritha, Kulkarni, Priyanka, Shiina, Marisa, Hashimoto, Yutaka, Shahryari, Varahram, Majid, Shahana, Tanaka, Yuichiro, Dahiya, Rajvir, Yamamura, Soichiro
• Format: Journal Article
• Language: English
• Published: Germany Cell Physiol Biochem Press GmbH & Co KG 22.01.2020
• Subjects: Anticarcinogenic Agents - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Chromatin Assembly and Disassembly - drug effects; Gene Expression Regulation, Neoplastic - drug effects; Genistein - pharmacology; Humans; Kidney Neoplasms - drug therapy; Kidney Neoplasms - genetics; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - prevention & control; RNA, Long Noncoding - genetics; HOTAIR; SMARCB1; PRC2; Renal cancer; Genistein
• ISSN: 1015-8987; 1421-9778; 1421-9778; 1015-8987
• DOI: 10.33594/000000205

Genistein, a soy isoflavone, has been shown to have anti-cancer effects in various cancers including renal cancer. Long non-coding RNA, HOX transcript antisense RNA (HOTAIR), is involved in cancer progression and metastasis, such as renal cancer. Our aim was to investigate the effects of genistein o...