Comparative Effects of Variations in Duodenal Glucose Load on Glycemic, Insulinemic, and Incretin Responses in Healthy Young and Older Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 97; no. 3; pp. 844 - 851
• Main Authors: Trahair, Laurence G., Horowitz, Michael, Rayner, Christopher K., Gentilcore, Diana, Lange, Kylie, Wishart, Judith M., Jones, Karen L.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.03.2012; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Age Factors; Aged; Aging; Beta cells; Biological and medical sciences; Blood glucose; Blood Glucose - metabolism; Double-Blind Method; Duodenum - drug effects; Duodenum - metabolism; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastric emptying; Gastric Emptying - drug effects; Gastric Inhibitory Polypeptide - blood; GIP protein; Glucagon; Glucagon-like peptide 1; Glucagon-Like Peptide 1 - blood; Glucose; Glucose - pharmacology; Glucose tolerance; Hormone release; Humans; Incretins - blood; Insulin - blood; Insulin resistance; Insulin Resistance - physiology; Male; Medical sciences; Postprandial Period - drug effects; Small intestine; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Young Adult; Human; Obesity; Incretin; Duodenum; Healthy subject; Nutrition; Digestive system; Nutrition disorder; Variations; Metabolic diseases; Glucose tolerance test; Small intestine; Elderly; Endocrinology; Nutritional status; Comparative study; Glycemia

Context:Aging is associated with deteriorating glucose tolerance. Studies assessing glucose tolerance and subsequent insulin and incretin hormone release often fail to take into account the rate of gastric emptying when evaluating these responses.Objective:Our objective was to determine the comparat...