Subtle Cognitive Impairments in Patients with Long-Term Cure of Cushing’s Disease

• Published in: The journal of clinical endocrinology and metabolism Vol. 95; no. 6; pp. 2699 - 2714
• Main Authors: Tiemensma, Jitske, Kokshoorn, Nieke E., Biermasz, Nienke R., Keijser, Bart-Jan S. A., Wassenaar, Moniek J. E., Middelkoop, Huub A. M., Pereira, Alberto M., Romijn, Johannes A.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.06.2010; Copyright by The Endocrine Society; Endocrine Society
• Subjects: ACTH-Secreting Pituitary Adenoma - complications; ACTH-Secreting Pituitary Adenoma - psychology; ACTH-Secreting Pituitary Adenoma - surgery; Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adrenocorticotropic hormone; Adult; Aged; Anxiety - psychology; Biological and medical sciences; Central nervous system; Clinical trials; Cognition Disorders - etiology; Cognition Disorders - psychology; Cognitive ability; Depression - psychology; Endocrinopathies; Executive function; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gender; Humans; Imprinting; Male; Medical sciences; Memory; Memory - physiology; Memory, Short-Term - physiology; Middle Aged; Nervous system diseases; Neuropsychological Tests; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pituitary; Pituitary ACTH Hypersecretion - complications; Pituitary ACTH Hypersecretion - psychology; Pituitary ACTH Hypersecretion - surgery; Pituitary Function Tests; Psychiatric Status Rating Scales; Survivors; Treatment Outcome; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Wechsler Scales; Endocrinopathy; Human; Obesity; Cognitive disorder; Adrenal cortex diseases; Nutrition; Cure; Nutrition disorder; Cushing syndrome; Patient; Metabolic diseases; Hyperadrenocorticism; Long term; Adrenal gland diseases; Endocrinology; Nutritional status

Context and Objective: Active Cushing’s disease is associated with cognitive impairments. We hypothesized that previous hypercortisolism in patients with Cushing’s disease results in irreversible impairments in cognitive functioning. Therefore, our aim was to assess cognitive functioning after long-...