Metabonomic analysis of the anti-inflammatory effects of volatile oils of Angelica sinensis on rat model of acute inflammation

• Published in: Biomedical chromatography Vol. 29; no. 6; pp. 902 - 910
• Main Authors: Zhang, Wen-quan, Hua, Yong-li, Zhang, Man, Ji, Peng, Li, Jin-xia, Zhang, Ling, Li, Peng-ling, Wei, Yan-ming
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2015
• Subjects: acute inflammation; Angelica sinensis; Angelica sinensis - chemistry; Animals; Carrageenan - adverse effects; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; GC-MS; Inflammation - chemically induced; Inflammation - metabolism; Male; Metabolic Networks and Pathways - drug effects; Metabolome - drug effects; Metabolomics; metabonomics; Multivariate Analysis; Oils, Volatile - pharmacology; Rats; Rats, Wistar; volatile oil; GC-MS; metabonomics; volatile oil; acute inflammation; Angelica sinensis

Metabonomics based on GC‐MS was used to study the possible anti‐inflammatory mechanisms of volatile oils of Angelica sinensis (VOAS) in rats with acute inflammation. Acute inflammation was induced by subcutaneous injection of carrageenan in rats. The levels of prostaglandin E2 (PGE2), histamine (HIS...