Galα1-4Galβ1-3GalNAc is the dominant epitope of Em2 antigen, the mucin-type glycoprotein from Echinococcus multilocularis

• Published in: Parasitology research (1987) Vol. 111; no. 2; pp. 795 - 805
• Main Authors: Yamano, Kimiaki, Koizumi, Akihiko, Takeda, Tadahiro, Kiuchi, Fumiyuki, Hada, Noriyasu
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2012; Springer
• Subjects: Animals; Antibodies; Antigens; Antigens, Helminth; Antigens, Helminth - chemistry; Antigens, Helminth - metabolism; Biomedical and Life Sciences; Biomedicine; Carbohydrate Conformation; Cestoda; chemistry; cross reaction; Diphyllobothrium; echinococcosis; Echinococcus granulosus; Echinococcus multilocularis; Echinococcus multilocularis - metabolism; Enzyme-Linked Immunosorbent Assay; Epitopes; Epitopes - chemistry; Epitopes - immunology; Glycoproteins; Glycoproteins - immunology; Glycoproteins - metabolism; Health aspects; helminths; hosts; humans; Immunology; larvae; Medical Microbiology; metabolism; Microbiology; oligosaccharides; Original Paper; Physiological aspects; recombinant antigens; serodiagnosis; Trematoda; Japan; Cystic Echinococcosis; Common Epitope; Echinococcosis; Alveolar Echinococcosis

The larval stage of Echinococcus multilocularis causes alveolar echinococcosis in human. In serodiagnosis of alveolar echinococcosis, specific reactions have been noted not only against protein antigens but also carbohydrates. With regard to protein antigens, the recent development of recombinant an...