Full-mouth disinfection as a therapeutic protocol for type-2 diabetic subjects with chronic periodontitis: Twelve-month clinical outcomes. A randomized controlled clinical trial

• Published in: Journal of clinical periodontology Vol. 40; no. 2; pp. 155 - 162
• Main Authors: Santos, Vanessa R., Lima, Jadson A., Miranda, Tamires S., Gonçalves, Tiago E. D., Figueiredo, Luciene C., Faveri, Marcelo, Duarte, Poliana M.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.02.2013; Blackwell
• Subjects: Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local - blood; Anti-Infective Agents, Local - therapeutic use; Biological and medical sciences; chlorhexidine; Chlorhexidine - therapeutic use; chronic periodontitis; Chronic Periodontitis - complications; Chronic Periodontitis - drug therapy; Clinical outcomes; Dental Scaling; Dentistry; Diabetes; diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; disinfection; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiology. Vaccinations; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Gels; General aspects; Glycated Hemoglobin A - analysis; Gum disease; Humans; Infectious diseases; Male; Medical sciences; Middle Aged; Non tumoral diseases; Otorhinolaryngology. Stomatology; Periodontal Attachment Loss - pathology; Prospective Studies; root planing; root scaling; Single-Blind Method; Statistics, Nonparametric; Treatment Outcome; Endocrinopathy; Type 2 diabetes; Human; root scaling; Prognosis; Stomatology; chronic periodontitis; Metabolic diseases; Disinfection; Guanidines; diabetes mellitus; Dentistry; root planing; Tooth root; Oral cavity; Periodontal disease; Chronic; Biguanides; Periodontitis; Antiseptic; Clinical trial; Chlorhexidine; Disinfecting agent; Therapeutic protocol
• ISSN: 0303-6979; 1600-051X; 1600-051X
• DOI: 10.1111/jcpe.12040

Aim The aim of this randomized controlled clinical trial was to evaluate the clinical effects of chlorhexidine (CHX) application in a full‐mouth disinfection (FMD) protocol in poorly controlled type‐2 diabetic subjects with generalized chronic periodontitis. Material and Methods Thirty‐eight subjects were randomly assigned into FMD group (n=19): full‐mouth scaling and root planing (FMSRP) within 24 h + local application of CHX gel + CHX rinses for 60 days or Control group (n = 19): FMSRP within 24 h + local application of placebo gel + placebo rinses for 60 days. Clinical parameters, glycated haemoglobin and fasting plasma glucose were assessed at baseline, 3, 6 and 12 months post‐therapies. Results All clinical parameters improved significantly at 3, 6 and 12 months post‐therapies for both groups (p < 0.05). There were no significant differences between groups for any clinical parameters, and glycemic condition at any time‐point (p > 0.05). Conclusions The treatments did not differ with respect to clinical parameters, including the primary outcome variable (i.e. changes in clinical attachment level in deep pockets), for up to 12 months post‐treatments.