Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP

• Published in: The Journal of biological chemistry Vol. 294; no. 52; pp. 19831 - 19843
• Main Authors: Lee, Hon Cheung, Zhao, Yong Juan
• Format: Journal Article
• Language: English
• Published: 11200 Rockville Pike, Suite 302, Rockville, MD 20852-3110, U.S.A Elsevier Inc 27.12.2019; American Society for Biochemistry and Molecular Biology
• Subjects: calcium intracellular release; calcium signaling; CD38; cyclic ADP ribose (cADPR); JBC Reviews; nicotinic acid adenine dinucleotide phosphate (NAADP); protein topology; SARM1; signal transduction; cyclic ADP ribose (cADPR); signal transduction; protein topology; calcium signaling; calcium intracellular release; SARM1; CD38; nicotinic acid adenine dinucleotide phosphate (NAADP)

Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two structurally distinct messengers that mobilize the endoplasmic and endolysosomal Ca2+ stores, respectively. Both are synthesized by the CD38 molecule (CD38), which has long been thought to be a type II membra...