Investigating Sexual Dimorphism of Human White Matter in a Harmonized, Multisite Diffusion Magnetic Resonance Imaging Study

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 31; no. 1; pp. 201 - 212
• Main Authors: Seitz, Johanna, Cetin-Karayumak, Suheyla, Lyall, Amanda, Pasternak, Ofer, Baxi, Madhura, Vangel, Mark, Pearlson, Godfrey, Tamminga, Carol, Sweeney, John, Clementz, Brett, Schretlen, David, Viher, Petra Verena, Stegmayer, Katharina, Walther, Sebastian, Lee, Jungsun, Crow, Tim, James, Anthony, Voineskos, Aristotle, Buchanan, Robert W, Szeszko, Philip R, Malhotra, Anil, Keshavan, Matcheri, Koerte, Inga K, Shenton, Martha E, Rathi, Yogesh, Kubicki, Marek
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.01.2021
• Subjects: Adolescent; Adult; Aged; Aging; Anisotropy; Axons - physiology; Child; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Female; Humans; Limbic System - diagnostic imaging; Limbic System - physiology; Male; Middle Aged; Myelin Sheath - physiology; Neural Pathways - diagnostic imaging; Neural Pathways - physiology; Original; Sex Characteristics; White Matter - anatomy & histology; White Matter - diagnostic imaging; Young Adult; fractional anisotropy; connectivity; female; male; diffusion-weighted MRI

Abstract Axonal myelination and repair, critical processes for brain development, maturation, and aging, remain controlled by sexual hormones. Whether this influence is reflected in structural brain differences between sexes, and whether it can be quantified by neuroimaging, remains controversial. D...