Clinical Use of Mesenchymal Stromal Cells in the Treatment of Acute Graft-versus-Host Disease

• Published in: Transfusion medicine and hemotherapy Vol. 46; no. 1; pp. 27 - 34
• Main Authors: Elgaz, Sümeyye, Kuçi, Zyrafete, Kuçi, Selim, Bönig, Halvard, Bader, Peter
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.02.2019
• Subjects: Review; Review Article; Mesenchymal stromal cells; Allogeneic stem cell transplantation; Steroid-refractory acute graft-versus-host disease

Acute graft-versus-host disease (aGvHD) continues to impact morbidity and mortality after allogeneic stem cell transplantation (allo-SCT). First-line therapy for aGvHD still remains the use of high-dose corticosteroids. Unfortunately, 40–60% of patients with aGvHD exhibit steroid resistance, which i...