Avian genomics and the innate immune response to viruses

Viral diseases pose a significant threat to the poultry industry. However, there is currently a lack of antivirals and suitable vaccine adjuvants available to the poultry industry to combat this problem. The innate immune system is now recognised to be essential in the response to viral infection. H...

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Bibliographic Details
Published inCytogenetic and genome research Vol. 117; no. 1-4; pp. 207 - 212
Main Authors Jenkins, K.A., Bean, A.G.D., Lowenthal, J.W.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.07.2007
Subjects
Animals
Birds - genetics
Birds - immunology
Birds - metabolism
Genomics
Humans
Immunity, Innate - genetics
Immunity, Innate - immunology
Immunology
Toll-Like Receptors - classification
Toll-Like Receptors - genetics
Toll-Like Receptors - immunology
Toll-Like Receptors - metabolism
Virus Diseases - genetics
Virus Diseases - immunology
Virus Diseases - metabolism
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Summary:Viral diseases pose a significant threat to the poultry industry. However, there is currently a lack of antivirals and suitable vaccine adjuvants available to the poultry industry to combat this problem. The innate immune system is now recognised to be essential in the response to viral infection. However, in contrast to mammals, the innate immune response in chickens is relatively uncharacterised. The release of the full chicken genome sequence has accelerated the identification of genes involved in the immune response. The characterisation of these genes, including Toll-like receptors and cytokines has led to the identification of potential alternate antivirals and adjuvants.
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ISBN:3805583389
9783805583381
ISSN:1424-8581
1424-859X
DOI:10.1159/000103181