CAR-Expressing Natural Killer Cells for Cancer Retargeting

• Published in: Transfusion medicine and hemotherapy Vol. 46; no. 1; pp. 4 - 13
• Main Authors: Kloess, Stephan, Kretschmer, Anna, Stahl, Lilly, Fricke, Stephan, Koehl, Ulrike
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.02.2019
• Subjects: Review; Review Article; Natural killer cells; Chimeric antigen receptor; NK-92; Haematological malignancies; Solid tumour; CAR-NK cell

Since the approval in 2017 and the outstanding success of Kymriah® and Yescarta®, the number of clinical trials investigating the safety and efficacy of chimeric antigen receptor-modified autologous T cells has been constantly rising. Currently, more than 200 clinical trials are listed on clinicaltr...