Population Pharmacokinetic and Pharmacodynamic Modeling of Artemisinin Resistance in Southeast Asia

• Published in: The AAPS journal Vol. 19; no. 6; pp. 1842 - 1854
• Main Authors: Lohy Das, Jesmin, Dondorp, Arjen M., Nosten, Francois, Phyo, Aung Pyae, Hanpithakpong, Warunee, Ringwald, Pascal, Lim, Pharath, White, Nicholas J., Karlsson, Mats O., Bergstrand, Martin, Tarning, Joel
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2017
• Subjects: Adolescent; Adult; Antimalarials - pharmacokinetics; Artemisinins - pharmacokinetics; Artemisinins - pharmacology; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Drug Resistance; Female; Humans; Malaria - drug therapy; Male; Models, Biological; Nomograms; Pharmacology/Toxicology; Pharmacy; Population Biology; Populationsbiologi; Research Article; Young Adult; pharmacokinetics; malaria; pharmacodynamics; resistance; parasite clearance

Orally administered artemisinin-based combination therapy is the first-line treatment against uncomplicated P. falciparum malaria worldwide. However, the increasing prevalence of artemisinin resistance is threatening efforts to treat and eliminate malaria in Southeast Asia. This study aimed to chara...