Low-Density Neutrophils Contribute to Subclinical Inflammation in Patients with Type 2 Diabetes

• Published in: International journal of molecular sciences Vol. 25; no. 3; p. 1674
• Main Authors: Dumont, Benjamin L., Neagoe, Paul-Eduard, Charles, Elcha, Villeneuve, Louis, Tardif, Jean-Claude, Räkel, Agnès, White, Michel, Sirois, Martin G.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2024
• Subjects: Biomarkers; C-reactive protein; Chronic illnesses; Cytokines; Diabetes; Diabetics; Disease; Enzyme-linked immunosorbent assay; Enzymes; Expenditures; Flow cytometry; Inflammation; Interleukins; Lymphocytes; Neutrophils; Type 2 diabetes; Canada; Ontario; Quebec; NETs; cytokines; type 2 diabetes; neutrophil

Type 2 diabetes (T2D) is characterized by low-grade inflammation. Low-density neutrophils (LDNs) represent normally less than 2% of total neutrophils but increase in multiple pathologies, releasing inflammatory cytokines and neutrophil extracellular traps (NETs). We assessed the count and role of hi...