Smart Interface for Reliable Intradermal Injection and Infusion of High and Low Viscosity Solutions

• Published in: Pharmaceutical research Vol. 28; no. 3; pp. 647 - 661
• Main Authors: Vosseler, Michael, Jugl, Michael, Zengerle, Roland
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.03.2011; Springer US; Springer; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biological and medical sciences; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; drug delivery; Drug Delivery Systems - instrumentation; Drug Delivery Systems - methods; General pharmacology; infusion; Infusion Pumps; injection; Injections; Injections, Intradermal; intradermal; Medical Law; Medical sciences; microneedle; Pharmaceutical sciences; Pharmaceutical Solutions - administration & dosage; Pharmaceutical Solutions - pharmacokinetics; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacy; Reproducibility of Results; Research Paper; Skin Absorption - drug effects; Skin Absorption - physiology; Swine; Transdermal medication; Viscosity; microneedle; drug delivery; infusion; injection; intradermal; Delivery system; Viscosity; Pharmaceutical technology; Perfusion; Drug carrier; Microneedle; Solution

Purpose We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. Methods The intradermal interface is based o...