Smart Interface for Reliable Intradermal Injection and Infusion of High and Low Viscosity Solutions

Purpose We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. Methods The intradermal interface is based o...

Full description

Saved in:
Bibliographic Details
Published inPharmaceutical research Vol. 28; no. 3; pp. 647 - 661
Main Authors Vosseler, Michael, Jugl, Michael, Zengerle, Roland
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.03.2011
Springer US
Springer
Springer Nature B.V
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Purpose We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. Methods The intradermal interface is based on a 31-gauge cannula embedded in a slider, movable relative to a carrier plate that can easily be fixed onto the skin. By simply pushing the slider, the cannula is inserted into the dermis. Results We performed injections and infusions with stained water and polyethylene glycol (PEG) solution in ex vivo pig skin. The sizes of coloured spots in the skin range from 3.5 mm² to 15.4 mm² for stained water depending on the infused volume. Infusing stained PEG solution resulted in stained tissue areas about one order of magnitude larger. One of three investigated leakage modes is unacceptable but can be reliably avoided by proper site selection. At low flow rates and at the beginning of an infusion an initial back pressure overshoot was identified. This effect was identified as the limiting parameter for the design of small programmable or intelligent devices based on micro actuators. Conclusions With the proposed easy-to-use interface, intradermal injections and infusions can be performed reliably. Therefore, it is supposed to be an ideal and clinically relevant solution for self-administration of parenteral drugs in home care applications.
AbstractList Purpose We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. Methods The intradermal interface is based on a 31-gauge cannula embedded in a slider, movable relative to a carrier plate that can easily be fixed onto the skin. By simply pushing the slider, the cannula is inserted into the dermis. Results We performed injections and infusions with stained water and polyethylene glycol (PEG) solution in ex vivo pig skin. The sizes of coloured spots in the skin range from 3.5 mm² to 15.4 mm² for stained water depending on the infused volume. Infusing stained PEG solution resulted in stained tissue areas about one order of magnitude larger. One of three investigated leakage modes is unacceptable but can be reliably avoided by proper site selection. At low flow rates and at the beginning of an infusion an initial back pressure overshoot was identified. This effect was identified as the limiting parameter for the design of small programmable or intelligent devices based on micro actuators. Conclusions With the proposed easy-to-use interface, intradermal injections and infusions can be performed reliably. Therefore, it is supposed to be an ideal and clinically relevant solution for self-administration of parenteral drugs in home care applications.
We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. The intradermal interface is based on a 31-gauge cannula embedded in a slider, movable relative to a carrier plate that can easily be fixed onto the skin. By simply pushing the slider, the cannula is inserted into the dermis. We performed injections and infusions with stained water and polyethylene glycol (PEG) solution in ex vivo pig skin. The sizes of coloured spots in the skin range from 3.5 mm(2) to 15.4 mm(2) for stained water depending on the infused volume. Infusing stained PEG solution resulted in stained tissue areas about one order of magnitude larger. One of three investigated leakage modes is unacceptable but can be reliably avoided by proper site selection. At low flow rates and at the beginning of an infusion an initial back pressure overshoot was identified. This effect was identified as the limiting parameter for the design of small programmable or intelligent devices based on micro actuators. With the proposed easy-to-use interface, intradermal injections and infusions can be performed reliably. Therefore, it is supposed to be an ideal and clinically relevant solution for self-administration of parenteral drugs in home care applications.
ABSTRACT Purpose We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. Methods The intradermal interface is based on a 31-gauge cannula embedded in a slider, movable relative to a carrier plate that can easily be fixed onto the skin. By simply pushing the slider, the cannula is inserted into the dermis. Results We performed injections and infusions with stained water and polyethylene glycol (PEG) solution in ex vivo pig skin. The sizes of coloured spots in the skin range from 3.5 mm 2 to 15.4 mm 2 for stained water depending on the infused volume. Infusing stained PEG solution resulted in stained tissue areas about one order of magnitude larger. One of three investigated leakage modes is unacceptable but can be reliably avoided by proper site selection. At low flow rates and at the beginning of an infusion an initial back pressure overshoot was identified. This effect was identified as the limiting parameter for the design of small programmable or intelligent devices based on micro actuators. Conclusions With the proposed easy-to-use interface, intradermal injections and infusions can be performed reliably. Therefore, it is supposed to be an ideal and clinically relevant solution for self-administration of parenteral drugs in home care applications.
We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. The intradermal interface is based on a 31-gauge cannula embedded in a slider, movable relative to a carrier plate that can easily be fixed onto the skin. By simply pushing the slider, the cannula is inserted into the dermis. We performed injections and infusions with stained water and polyethylene glycol (PEG) solution in ex vivo pig skin. The sizes of coloured spots in the skin range from 3.5 mm^sup 2^ to 15.4 mm^sup 2^ for stained water depending on the infused volume. Infusing stained PEG solution resulted in stained tissue areas about one order of magnitude larger. One of three investigated leakage modes is unacceptable but can be reliably avoided by proper site selection. At low flow rates and at the beginning of an infusion an initial back pressure overshoot was identified. This effect was identified as the limiting parameter for the design of small programmable or intelligent devices based on micro actuators. With the proposed easy-to-use interface, intradermal injections and infusions can be performed reliably. Therefore, it is supposed to be an ideal and clinically relevant solution for self-administration of parenteral drugs in home care applications.[PUBLICATION ABSTRACT]
Author Jugl, Michael
Vosseler, Michael
Zengerle, Roland
Author_xml – sequence: 1
  fullname: Vosseler, Michael
– sequence: 2
  fullname: Jugl, Michael
– sequence: 3
  fullname: Zengerle, Roland
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24036913$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/21104300$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtLAzEUhYNUtD5-gBsdBJejN695LKWoLRQEq-IupJmkTplOajKDtL_ejFN15yq5N985Nzk5QoPa1hqhMwzXGCC98RhDzmPAEAPFebzdQ0PMUxrnwN4GaAgpYXGWMnyIjrxfAkCGc3aADkkQMgowRGq2kq6JJnWjnZFKR8a66ElXpZxXums7WWi3klXYL7VqSltHsi5CZVrfFdZE43Lx_t2c2s_otfTK-rLZRDNbtR3vT9C-kZXXp7v1GL3c3z2PxvH08WEyup3GihHWxColaaILw4CzLJEpsKQolEpoxiEzhhFNaUpyylU-J5JTaQzNmSwSBgXnDNNjdNn7rp39aLVvxNK2rg4jRcZJEFPMA4R7SDnrvdNGrF0ZMtgIDKJLVfSpipCq6FIV26A53xm385UufhU_MQbgagdIr2RlnKxV6f84BjTJMQ0c6TkfjuqFdn83_G_6RS8y0gq5cMH4ZUYAUwifyZLwpi8dypnn
CODEN PHREEB
CitedBy_id crossref_primary_10_1016_j_vaccine_2016_09_069
crossref_primary_10_1109_TBME_2011_2174990
crossref_primary_10_1088_0964_1726_21_10_105002
crossref_primary_10_1016_j_ijpharm_2021_120530
crossref_primary_10_4274_turkderm_galenos_2022_06702
crossref_primary_10_1007_s11095_014_1611_0
Cites_doi 10.1088/0960-1317/14/4/021
10.1159/000112958
10.1016/j.jconrel.2006.11.009
10.1038/nbt.1504
10.1007/s00542-006-0173-4
10.1007/s10544-009-9311-y
10.1109/JMEMS.2005.844843
10.1002/jps.2600830432
10.1208/pt070126
10.1016/j.addr.2007.08.001
10.1007/s10404-008-0266-8
10.1016/j.snb.2007.10.064
10.1089/dia.2008.0103
10.1517/17425240902841935
10.1016/j.mee.2007.12.067
10.1086/590434
10.1016/j.vaccine.2008.10.077
10.1007/s10404-009-0467-9
10.1109/JMEMS.2003.809959
10.1007/s11095-005-8498-8
10.1016/j.jconrel.2008.02.009
10.1016/j.vaccine.2007.10.020
10.1007/BF00510085
10.1016/S0927-7757(00)00824-4
10.1007/s11095-009-9967-2
10.2174/1567201043480045
10.1016/0195-6701(95)90070-5
10.1109/JMEMS.2003.820293
ContentType Journal Article
Copyright Springer Science+Business Media, LLC 2010
2015 INIST-CNRS
Springer Science+Business Media, LLC 2011
Copyright_xml – notice: Springer Science+Business Media, LLC 2010
– notice: 2015 INIST-CNRS
– notice: Springer Science+Business Media, LLC 2011
DBID FBQ
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7RV
7TK
7X7
7XB
88E
8AO
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
FYUFA
GHDGH
K9.
KB0
M0S
M1P
NAPCQ
PQEST
PQQKQ
PQUKI
PRINS
DOI 10.1007/s11095-010-0319-z
DatabaseName AGRIS
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Nursing & Allied Health Database
Neurosciences Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central
ProQuest One Community College
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Nursing & Allied Health Premium
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Pharma Collection
Neurosciences Abstracts
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
DatabaseTitleList
MEDLINE

ProQuest One Academic Eastern Edition
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
– sequence: 4
  dbid: FBQ
  name: AGRIS
  url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1573-904X
EndPage 661
ExternalDocumentID 2268857831
10_1007_s11095_010_0319_z
21104300
24036913
US201301944615
Genre Research Support, Non-U.S. Gov't
Journal Article
Comparative Study
GroupedDBID ---
-4W
-56
-5G
-BR
-EM
-Y2
-~C
.86
.VR
06C
06D
0R~
0VY
123
199
1N0
1SB
2.D
203
28-
29O
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
3SX
3V.
4.4
406
408
409
40D
40E
53G
5QI
5VS
67N
67Z
6NX
78A
7RV
7X7
88E
8AO
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
AAAVM
AABHQ
AABYN
AAFGU
AAHNG
AAIAL
AAJKR
AANXM
AANZL
AARHV
AARTL
AATNV
AATVU
AAUYE
AAWCG
AAYFA
AAYIU
AAYOK
AAYQN
AAYTO
ABBBX
ABBXA
ABDZT
ABECU
ABELW
ABFGW
ABFTV
ABHLI
ABHQN
ABIPD
ABJNI
ABJOX
ABKAS
ABKCH
ABKTR
ABLJU
ABMNI
ABMQK
ABNWP
ABPLI
ABPTK
ABQBU
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABUWG
ABWNU
ABXPI
ACBMV
ACBRV
ACBXY
ACBYP
ACGFS
ACHSB
ACHXU
ACIGE
ACIPQ
ACIWK
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPRK
ACTTH
ACVWB
ACWMK
ADBBV
ADHHG
ADHIR
ADIMF
ADINQ
ADJJI
ADKNI
ADKPE
ADMDM
ADOAH
ADOXG
ADRFC
ADTPH
ADURQ
ADYFF
ADYPR
ADZKW
AEBTG
AEEQQ
AEFIE
AEFTE
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AENEX
AEOHA
AEPYU
AESKC
AESTI
AETLH
AEVLU
AEVTX
AEXYK
AFDYV
AFEXP
AFGCZ
AFKRA
AFLOW
AFNRJ
AFQWF
AFRAH
AFWTZ
AFZKB
AGAYW
AGDGC
AGGBP
AGGDS
AGJBK
AGMZJ
AGQMX
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHIZS
AHKAY
AHMBA
AHSBF
AHYZX
AIAKS
AIIXL
AILAN
AIMYW
AITGF
AJBLW
AJDOV
AJRNO
AJZVZ
AKMHD
AKQUC
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
AOSHJ
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
B-.
BA0
BBWZM
BDATZ
BENPR
BGNMA
BKEYQ
BPHCQ
BVXVI
CAG
CCPQU
COF
CS3
CSCUP
DDRTE
DL5
DNIVK
DPUIP
DU5
EBD
EBLON
EBS
EIOEI
EJD
EMOBN
EN4
EPAXT
ESBYG
EX3
F5P
FBQ
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
GQ8
GXS
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IAO
IHE
IJ-
IKXTQ
IMOTQ
INH
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KDC
KOV
KOW
KPH
L7B
LAK
LLZTM
LSO
M1P
M4Y
MA-
MK0
N2Q
N9A
NAPCQ
NB0
NDZJH
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
OVD
P19
P2P
PF0
PQQKQ
PROAC
PSQYO
PT4
PT5
Q2X
QOK
QOR
QOS
R4E
R89
R9I
RHV
RIG
RNI
RNS
ROL
RPX
RRX
RSV
RZC
RZE
RZK
S16
S1Z
S26
S27
S28
S3A
S3B
SAP
SBL
SBY
SCLPG
SDH
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
T16
TEORI
TSG
TSK
TSV
TUC
U2A
U9L
UG4
UKHRP
UNUBA
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WH7
WJK
WK6
WK8
WOW
YCJ
YLTOR
Z45
Z5O
Z7S
Z7U
Z7V
Z7W
Z7X
Z81
Z82
Z83
Z84
Z87
Z88
Z8N
Z8O
Z8P
Z8Q
Z8R
Z8V
Z8W
Z91
Z92
ZGI
ZMTXR
ZOVNA
~KM
AAPBV
H13
IQODW
AACDK
AAEOY
AAJBT
AAQLM
AASML
AAYZH
ABAKF
ACAOD
ACDTI
ACZOJ
AEFQL
AEMSY
AFBBN
AGQEE
AGRTI
AIGIU
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
ABQSL
CITATION
7TK
7XB
8FK
K9.
PQEST
PQUKI
PRINS
ID FETCH-LOGICAL-c424t-c7276edf405486a7046ddcc638508ff42e3372935c9b2a53aff394ad640d55413
IEDL.DBID 7X7
ISSN 0724-8741
IngestDate Thu Oct 10 19:44:12 EDT 2024
Fri Dec 06 02:07:11 EST 2024
Tue Oct 15 23:39:49 EDT 2024
Sun Oct 22 16:08:38 EDT 2023
Sat Dec 16 11:59:10 EST 2023
Wed Dec 27 19:06:27 EST 2023
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords microneedle
drug delivery
infusion
injection
intradermal
Delivery system
Viscosity
Pharmaceutical technology
Perfusion
Drug carrier
Microneedle
Solution
Language English
License CC BY 4.0
http://www.springer.com/tdm
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c424t-c7276edf405486a7046ddcc638508ff42e3372935c9b2a53aff394ad640d55413
Notes http://dx.doi.org/10.1007/s11095-010-0319-z
PMID 21104300
PQID 852337315
PQPubID 37334
PageCount 15
ParticipantIDs proquest_journals_852337315
crossref_primary_10_1007_s11095_010_0319_z
pubmed_primary_21104300
pascalfrancis_primary_24036913
springer_journals_10_1007_s11095_010_0319_z
fao_agris_US201301944615
PublicationCentury 2000
PublicationDate 2011-03-01
PublicationDateYYYYMMDD 2011-03-01
PublicationDate_xml – month: 03
  year: 2011
  text: 2011-03-01
  day: 01
PublicationDecade 2010
PublicationPlace Boston
PublicationPlace_xml – name: Boston
– name: New York, NY
– name: United States
– name: New York
PublicationSubtitle An Official Journal of the American Association of Pharmaceutical Scientists
PublicationTitle Pharmaceutical research
PublicationTitleAbbrev Pharm Res
PublicationTitleAlternate Pharm Res
PublicationYear 2011
Publisher Boston : Springer US
Springer US
Springer
Springer Nature B.V
Publisher_xml – name: Boston : Springer US
– name: Springer US
– name: Springer
– name: Springer Nature B.V
References Khumpuang, Horade, Fujioka, Sugiyama (CR12) 2007; 13
Prausnitz, Langer (CR6) 2008; 26
Iverson, Garimella (CR23) 2008; 5
Gupta, Felner, Prausnitz (CR4) 2009; 11
Bonnekoh, Wevers, Jugert, Merk, Mahrle (CR28) 1989; 281
Henning, Neumann, Kostka, Lehr, Schaefer (CR24) 2008; 21
Häfeli, Mokhtari, Liepmann, Stoeber (CR19) 2009; 11
Gardeniers, Luttge, Berenschot, de Boer, Yeshurun, Hefetz (CR8) 2003; 12
Nisar, AftuIpurkar, Mahaisavariya, Tuantranont (CR20) 2008; 130
Stoeber, Liepmann (CR10) 2005; 14
Griss, Stemme (CR9) 2003; 12
Holland, Booy, De Looze, Eizenberg, McDonald, Karrasch (CR1) 2008; 198
Verbaan, Bal, van den Berg, Dijksman, van Hecke, Verpoorten (CR15) 2008; 128
Banga (CR7) 2009; 6
Martanto, Moore, Kashlan, Kamath, Wang, O’Neal (CR11) 2006; 23
Bodhale, Nisar, Afzulpurkar (CR13) 2010; 8
Van Damme, Oosterhuis-Kafeja, Van der Wielen, Almagor, Sharon, Levin (CR3) 2009; 27
Donnelly, Singh, Tunney, Morrow, McCarron, O’Mahony (CR18) 2009; 26
Santhanalaksmi, Balaji (CR27) 2001; 186
Saji, Taguchi, Uchiyama, Osono, Hayama, Ohkuni (CR29) 1995; 31
Kim, Park, Lu, Che, Kim, Lee (CR14) 2004; 14
Sepassi, Yalkowsky (CR25) 2006; 7
Verbaan, Bal, van den Berg, Groenink, Verpoorten, Lüttge (CR16) 2007; 117
Matteucci, Casella, Bedoni, Donetti, Fanetti, De Angelis (CR21) 2008; 85
Heinemann, Pettis, Hirsch, Nosek, Kapitza, Sutter (CR17) 2009; 52
Lemmer (CR22) 2007; 59
Cross, Roberts (CR5) 2004; 1
Yamaoka, Tabata, Ikada (CR26) 1994; 83
Laurent, Bonnet, Alchas, Regolini, Mikszta, Pettis (CR2) 2007; 25
18023942 - Vaccine. 2007 Dec 17;25(52):8833-42
16308670 - Pharm Res. 2006 Jan;23(1):104-13
18187967 - Skin Pharmacol Physiol. 2008;21(2):81-8
19022318 - Vaccine. 2009 Jan 14;27(3):454-9
8046623 - J Pharm Sci. 1994 Apr;83(4):601-6
19348604 - Expert Opin Drug Deliv. 2009 Apr;6(4):343-54
19756972 - Pharm Res. 2009 Nov;26(11):2513-22
19459760 - Diabetes Technol Ther. 2009 Jun;11(6):329-37
16305373 - Curr Drug Deliv. 2004 Jan;1(1):81-92
16584157 - AAPS PharmSciTech. 2006 Mar 24;7(1):E26
17825947 - Adv Drug Deliv Rev. 2007 Aug 31;59(9-10):825-7
19347587 - Biomed Microdevices. 2009 Oct;11(5):943-50
17196697 - J Control Release. 2007 Feb 12;117(2):238-45
2482013 - Arch Dermatol Res. 1989;281(7):487-90
8586792 - J Hosp Infect. 1995 Nov;31(3):225-8
18997767 - Nat Biotechnol. 2008 Nov;26(11):1261-8
18652550 - J Infect Dis. 2008 Sep 1;198(5):650-8
18394741 - J Control Release. 2008 May 22;128(1):80-8
P Damme Van (319_CR3) 2009; 27
P Griss (319_CR9) 2003; 12
PE Laurent (319_CR2) 2007; 25
A Henning (319_CR24) 2008; 21
HJGE Gardeniers (319_CR8) 2003; 12
B Bonnekoh (319_CR28) 1989; 281
S Khumpuang (319_CR12) 2007; 13
S Cross (319_CR5) 2004; 1
M Matteucci (319_CR21) 2008; 85
FJ Verbaan (319_CR15) 2008; 128
B Lemmer (319_CR22) 2007; 59
D Holland (319_CR1) 2008; 198
J Santhanalaksmi (319_CR27) 2001; 186
T Yamaoka (319_CR26) 1994; 83
D Bodhale (319_CR13) 2010; 8
RF Donnelly (319_CR18) 2009; 26
A Nisar (319_CR20) 2008; 130
K Kim (319_CR14) 2004; 14
BD Iverson (319_CR23) 2008; 5
MR Prausnitz (319_CR6) 2008; 26
L Heinemann (319_CR17) 2009; 52
UO Häfeli (319_CR19) 2009; 11
B Stoeber (319_CR10) 2005; 14
AK Banga (319_CR7) 2009; 6
W Martanto (319_CR11) 2006; 23
FJ Verbaan (319_CR16) 2007; 117
J Gupta (319_CR4) 2009; 11
K Sepassi (319_CR25) 2006; 7
M Saji (319_CR29) 1995; 31
References_xml – volume: 14
  start-page: 597
  year: 2004
  end-page: 603
  ident: CR14
  article-title: A tapered hollow metallic microneedle array using backside exposure of SU-8
  publication-title: J Micromech Microeng
  doi: 10.1088/0960-1317/14/4/021
  contributor:
    fullname: Lee
– volume: 21
  start-page: 81
  year: 2008
  end-page: 8
  ident: CR24
  article-title: Influence of human skin specimens consisting of different skin layers on the result of permeation experiments
  publication-title: Skin Pharmacol Physiol
  doi: 10.1159/000112958
  contributor:
    fullname: Schaefer
– volume: 117
  start-page: 238
  year: 2007
  end-page: 45
  ident: CR16
  article-title: Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2006.11.009
  contributor:
    fullname: Lüttge
– volume: 26
  start-page: 1261
  year: 2008
  end-page: 8
  ident: CR6
  article-title: Transdermal drug delivery
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.1504
  contributor:
    fullname: Langer
– volume: 13
  start-page: 209
  year: 2007
  end-page: 14
  ident: CR12
  article-title: Geometrical strengthening and tip-sharpening of a microneedle array fabricated by X-ray lithography
  publication-title: Microsyst Technol
  doi: 10.1007/s00542-006-0173-4
  contributor:
    fullname: Sugiyama
– volume: 11
  start-page: 943
  year: 2009
  end-page: 50
  ident: CR19
  article-title: evaluation of a microneedle-based miniature syringe for intradermal drug delivery
  publication-title: Biomed Microdevices
  doi: 10.1007/s10544-009-9311-y
  contributor:
    fullname: Stoeber
– volume: 14
  start-page: 472
  year: 2005
  end-page: 9
  ident: CR10
  article-title: Arrays of hollow out-of-plane microneedles for drug delivery
  publication-title: J Microelectromech Syst
  doi: 10.1109/JMEMS.2005.844843
  contributor:
    fullname: Liepmann
– volume: 83
  start-page: 601
  year: 1994
  end-page: 8
  ident: CR26
  article-title: Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous adminsitration to mice
  publication-title: J Pharm Sci-US
  doi: 10.1002/jps.2600830432
  contributor:
    fullname: Ikada
– volume: 7
  start-page: E26
  year: 2006
  ident: CR25
  article-title: Solubility prediction in octanol: a technical note
  publication-title: AAPS PharmSciTech
  doi: 10.1208/pt070126
  contributor:
    fullname: Yalkowsky
– volume: 59
  start-page: 825
  year: 2007
  end-page: 7
  ident: CR22
  article-title: Chronobiology, drug-delivery, and chronotherapeutics
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2007.08.001
  contributor:
    fullname: Lemmer
– volume: 5
  start-page: 145
  year: 2008
  end-page: 74
  ident: CR23
  article-title: Recent advances in microscale pumping technologies: a review and evaluation
  publication-title: Microfluid Nanofluid
  doi: 10.1007/s10404-008-0266-8
  contributor:
    fullname: Garimella
– volume: 130
  start-page: 917
  year: 2008
  end-page: 42
  ident: CR20
  article-title: MEMS-based micropumps in drug delivery and biomedical applications
  publication-title: Sens Actuat B Chem
  doi: 10.1016/j.snb.2007.10.064
  contributor:
    fullname: Tuantranont
– volume: 11
  start-page: 329
  year: 2009
  end-page: 37
  ident: CR4
  article-title: Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles
  publication-title: Diabetes Technol Ther
  doi: 10.1089/dia.2008.0103
  contributor:
    fullname: Prausnitz
– volume: 6
  start-page: 343
  year: 2009
  end-page: 54
  ident: CR7
  article-title: Microporation applications for enhancing drug delivery
  publication-title: Expert Opin Drug Deliv
  doi: 10.1517/17425240902841935
  contributor:
    fullname: Banga
– volume: 85
  start-page: 1066
  year: 2008
  end-page: 73
  ident: CR21
  article-title: A compact and disposable transdermal drug delivery system
  publication-title: Microelectron Eng
  doi: 10.1016/j.mee.2007.12.067
  contributor:
    fullname: De Angelis
– volume: 198
  start-page: 650
  year: 2008
  end-page: 8
  ident: CR1
  article-title: Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial
  publication-title: J Infect Dis
  doi: 10.1086/590434
  contributor:
    fullname: Karrasch
– volume: 52
  start-page: 963
  year: 2009
  ident: CR17
  article-title: Microneedle-based intradermal injection of lispro or human regular insulin accelerates insulin uptake and reduces post-prandial glycaemia
  publication-title: Diabetologia
  contributor:
    fullname: Sutter
– volume: 27
  start-page: 454
  year: 2009
  end-page: 9
  ident: CR3
  article-title: Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2008.10.077
  contributor:
    fullname: Levin
– volume: 8
  start-page: 373
  year: 2010
  end-page: 92
  ident: CR13
  article-title: Structural and microfluidic analysis of hollow side-open polymeric microneedles for transdermal drug delivery applications
  publication-title: Microfluid_Nanofluid
  doi: 10.1007/s10404-009-0467-9
  contributor:
    fullname: Afzulpurkar
– volume: 12
  start-page: 296
  year: 2003
  end-page: 301
  ident: CR9
  article-title: Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer
  publication-title: J Microelectromech Syst
  doi: 10.1109/JMEMS.2003.809959
  contributor:
    fullname: Stemme
– volume: 23
  start-page: 104
  year: 2006
  end-page: 13
  ident: CR11
  article-title: Microinfusion using hollow microneedles
  publication-title: Pharm Res
  doi: 10.1007/s11095-005-8498-8
  contributor:
    fullname: O’Neal
– volume: 128
  start-page: 80
  year: 2008
  end-page: 8
  ident: CR15
  article-title: Improved peircing of microneedle arrays in dermatomed human skin by an impact insertion method
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2008.02.009
  contributor:
    fullname: Verpoorten
– volume: 25
  start-page: 8833
  year: 2007
  end-page: 42
  ident: CR2
  article-title: Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2007.10.020
  contributor:
    fullname: Pettis
– volume: 281
  start-page: 487
  year: 1989
  end-page: 790
  ident: CR28
  article-title: Colorimetric growth assy for epidermal cell cultures by their crystal violet binding capacity
  publication-title: Arch Dermatol Res
  doi: 10.1007/BF00510085
  contributor:
    fullname: Mahrle
– volume: 186
  start-page: 173
  year: 2001
  end-page: 7
  ident: CR27
  article-title: Binding studies of crytsal violet on proteins
  publication-title: Colloids Surf A
  doi: 10.1016/S0927-7757(00)00824-4
  contributor:
    fullname: Balaji
– volume: 26
  start-page: 2513
  year: 2009
  end-page: 22
  ident: CR18
  article-title: Microneedle arrays allow lower microbial penetration than hypodermic needles
  publication-title: Pharm Res
  doi: 10.1007/s11095-009-9967-2
  contributor:
    fullname: O’Mahony
– volume: 1
  start-page: 81
  year: 2004
  end-page: 92
  ident: CR5
  article-title: Physical enhancement of transdermal drug application: is delivery technology keeping up with pharmaceutical development?
  publication-title: Curr Drug Deliv
  doi: 10.2174/1567201043480045
  contributor:
    fullname: Roberts
– volume: 31
  start-page: 225
  year: 1995
  end-page: 8
  ident: CR29
  article-title: Efficacy of gentian violet in the eradication of methicillin-resistant staphylococcus aureus from skin lesions
  publication-title: J Hosp Infect
  doi: 10.1016/0195-6701(95)90070-5
  contributor:
    fullname: Ohkuni
– volume: 12
  start-page: 855
  year: 2003
  end-page: 62
  ident: CR8
  article-title: Silicon micromachined hollow microneedles for transdermal liquid transport
  publication-title: J Microelectromech Syst
  doi: 10.1109/JMEMS.2003.820293
  contributor:
    fullname: Hefetz
– volume: 8
  start-page: 373
  year: 2010
  ident: 319_CR13
  publication-title: Microfluid_Nanofluid
  doi: 10.1007/s10404-009-0467-9
  contributor:
    fullname: D Bodhale
– volume: 27
  start-page: 454
  year: 2009
  ident: 319_CR3
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2008.10.077
  contributor:
    fullname: P Damme Van
– volume: 12
  start-page: 855
  year: 2003
  ident: 319_CR8
  publication-title: J Microelectromech Syst
  doi: 10.1109/JMEMS.2003.820293
  contributor:
    fullname: HJGE Gardeniers
– volume: 7
  start-page: E26
  year: 2006
  ident: 319_CR25
  publication-title: AAPS PharmSciTech
  doi: 10.1208/pt070126
  contributor:
    fullname: K Sepassi
– volume: 186
  start-page: 173
  year: 2001
  ident: 319_CR27
  publication-title: Colloids Surf A
  doi: 10.1016/S0927-7757(00)00824-4
  contributor:
    fullname: J Santhanalaksmi
– volume: 198
  start-page: 650
  year: 2008
  ident: 319_CR1
  publication-title: J Infect Dis
  doi: 10.1086/590434
  contributor:
    fullname: D Holland
– volume: 13
  start-page: 209
  year: 2007
  ident: 319_CR12
  publication-title: Microsyst Technol
  doi: 10.1007/s00542-006-0173-4
  contributor:
    fullname: S Khumpuang
– volume: 31
  start-page: 225
  year: 1995
  ident: 319_CR29
  publication-title: J Hosp Infect
  doi: 10.1016/0195-6701(95)90070-5
  contributor:
    fullname: M Saji
– volume: 26
  start-page: 1261
  year: 2008
  ident: 319_CR6
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.1504
  contributor:
    fullname: MR Prausnitz
– volume: 59
  start-page: 825
  year: 2007
  ident: 319_CR22
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2007.08.001
  contributor:
    fullname: B Lemmer
– volume: 5
  start-page: 145
  year: 2008
  ident: 319_CR23
  publication-title: Microfluid Nanofluid
  doi: 10.1007/s10404-008-0266-8
  contributor:
    fullname: BD Iverson
– volume: 117
  start-page: 238
  year: 2007
  ident: 319_CR16
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2006.11.009
  contributor:
    fullname: FJ Verbaan
– volume: 14
  start-page: 472
  year: 2005
  ident: 319_CR10
  publication-title: J Microelectromech Syst
  doi: 10.1109/JMEMS.2005.844843
  contributor:
    fullname: B Stoeber
– volume: 12
  start-page: 296
  year: 2003
  ident: 319_CR9
  publication-title: J Microelectromech Syst
  doi: 10.1109/JMEMS.2003.809959
  contributor:
    fullname: P Griss
– volume: 26
  start-page: 2513
  year: 2009
  ident: 319_CR18
  publication-title: Pharm Res
  doi: 10.1007/s11095-009-9967-2
  contributor:
    fullname: RF Donnelly
– volume: 83
  start-page: 601
  year: 1994
  ident: 319_CR26
  publication-title: J Pharm Sci-US
  doi: 10.1002/jps.2600830432
  contributor:
    fullname: T Yamaoka
– volume: 21
  start-page: 81
  year: 2008
  ident: 319_CR24
  publication-title: Skin Pharmacol Physiol
  doi: 10.1159/000112958
  contributor:
    fullname: A Henning
– volume: 128
  start-page: 80
  year: 2008
  ident: 319_CR15
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2008.02.009
  contributor:
    fullname: FJ Verbaan
– volume: 6
  start-page: 343
  year: 2009
  ident: 319_CR7
  publication-title: Expert Opin Drug Deliv
  doi: 10.1517/17425240902841935
  contributor:
    fullname: AK Banga
– volume: 14
  start-page: 597
  year: 2004
  ident: 319_CR14
  publication-title: J Micromech Microeng
  doi: 10.1088/0960-1317/14/4/021
  contributor:
    fullname: K Kim
– volume: 85
  start-page: 1066
  year: 2008
  ident: 319_CR21
  publication-title: Microelectron Eng
  doi: 10.1016/j.mee.2007.12.067
  contributor:
    fullname: M Matteucci
– volume: 11
  start-page: 329
  year: 2009
  ident: 319_CR4
  publication-title: Diabetes Technol Ther
  doi: 10.1089/dia.2008.0103
  contributor:
    fullname: J Gupta
– volume: 1
  start-page: 81
  year: 2004
  ident: 319_CR5
  publication-title: Curr Drug Deliv
  doi: 10.2174/1567201043480045
  contributor:
    fullname: S Cross
– volume: 23
  start-page: 104
  year: 2006
  ident: 319_CR11
  publication-title: Pharm Res
  doi: 10.1007/s11095-005-8498-8
  contributor:
    fullname: W Martanto
– volume: 11
  start-page: 943
  year: 2009
  ident: 319_CR19
  publication-title: Biomed Microdevices
  doi: 10.1007/s10544-009-9311-y
  contributor:
    fullname: UO Häfeli
– volume: 25
  start-page: 8833
  year: 2007
  ident: 319_CR2
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2007.10.020
  contributor:
    fullname: PE Laurent
– volume: 130
  start-page: 917
  year: 2008
  ident: 319_CR20
  publication-title: Sens Actuat B Chem
  doi: 10.1016/j.snb.2007.10.064
  contributor:
    fullname: A Nisar
– volume: 281
  start-page: 487
  year: 1989
  ident: 319_CR28
  publication-title: Arch Dermatol Res
  doi: 10.1007/BF00510085
  contributor:
    fullname: B Bonnekoh
– volume: 52
  start-page: 963
  year: 2009
  ident: 319_CR17
  publication-title: Diabetologia
  contributor:
    fullname: L Heinemann
SSID ssj0008194
Score 2.0632746
Snippet Purpose We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less...
ABSTRACT Purpose We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that...
We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive...
SourceID proquest
crossref
pubmed
pascalfrancis
springer
fao
SourceType Aggregation Database
Index Database
Publisher
StartPage 647
SubjectTerms Animals
Biochemistry
Biological and medical sciences
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
drug delivery
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
General pharmacology
infusion
Infusion Pumps
injection
Injections
Injections, Intradermal
intradermal
Medical Law
Medical sciences
microneedle
Pharmaceutical sciences
Pharmaceutical Solutions - administration & dosage
Pharmaceutical Solutions - pharmacokinetics
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Reproducibility of Results
Research Paper
Skin Absorption - drug effects
Skin Absorption - physiology
Swine
Transdermal medication
Viscosity
SummonAdditionalLinks – databaseName: SpringerLINK - Czech Republic Consortium
  dbid: AGYKE
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9wwEB7xuPRSKNASoMiHikMhqyR2vJvjCvFqS4UEW9GT5fiBWkQWkV2h3V_PTLLZCAEHjrEydmLPeD7PywDfetJ4VFQmjPI4D4WPZahTnoQ2zTVHBsmcIzvk-W95OhA_rtPrBUjmpovittN4JKuNus11iyNKJibfLSXeTBdhGVUPCeNy_-Tvz6P5_os6rioa1U0EyrqIG1_ma50800aLXg8pNlKXOD2-vtfiNeD5wmla6aLjlTo_sKxKGFIIym1nPMo7ZvqywOM7fnMVPs6gKevXvPQJFlyxBnsXdW3ryQG7alO1ygO2xy7aqteTdXB9dnmHfMgqG6PXxjHEw4xCnik7i5ofKGr6Doc4K_5XEWAF04XFJz8mmx0bekZhJ1Xjr-Ej-_OvNBRTNmFz490GDI6Prg5Pw9kdDqERiRiFBvGRdNYjLhQ9qbt4HLfWGJR6RIbei8Rxchzy1GR5glyiveeZ0FaKyCLSiflnWCqGhdsEFjnnfCa1sLkVOjc6Q8LUyZ7hUWRsHMD3Zi3VfV2qQ7VFmWlaFU6romlV0wA2cbWVvsGtVA0uE3LgIt8IBHgB7D5jgXlnVLpQZjEPYLvhCTWT-FL18ETPu5zIv9Rs0tLh4AK_MYD9Zs1buje_cOtdb2_Dh9raTdFxO7A0ehi7rwiXRvnuTD6eAJ1iCWI
  priority: 102
  providerName: Springer Nature
Title Smart Interface for Reliable Intradermal Injection and Infusion of High and Low Viscosity Solutions
URI https://link.springer.com/article/10.1007/s11095-010-0319-z
https://www.ncbi.nlm.nih.gov/pubmed/21104300
https://www.proquest.com/docview/852337315
Volume 28
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7R9sIFUV4NLSsfUA_QiDh2spsT2kW7lNdqRbtoOVmOHwikJqXZCm1_PTN5bFTxOEVJ5NjKN_aMZ74ZAzwfpcajojJhlPM8lJ6noU5EHNok1wIFJHOO_JCf5unpUr5fJauWm1O1tMpuTawXalsa8pG_GuGOSQwFT15f_gzp0CgKrrYnaOzAHo9Rk6M4D1fb_RYpu7p61DCWOOkl74KadeYcjyg1mSLBlMZzc0st7XhdEklSV_iffHPAxd8s0D-ip7VSmt2He601ycYN_PtwxxUP4HjRlKPenLDzPruqOmHHbNEXqt48BDdmZxcoOqx2C3ptHEMTlhFLmRKq6PEVEZ0vsIt3xY-atFUwXVi889fkZmOlZ8QUqR9-LH-xL98rQzSwDdv62x7BcjY9f3MatscuhEbGch0aNGlSZz2acnKU6iHuoK01BicqGnPey9gJivWJxGR5jMBq70UmtU1lZNE44eIx7BZl4Q6ARc45n6Va2txKnRudYcPEpSMjoshYHsCL7q-ry6a6hurrKBNECiFSBJG6CeAAcVH6G65-ankWU8wVEZZokwUwuAXW9mNUbTDNuAjgsENPtZO0UluRCuBJA2jfDjuXOMYAXnYI9-3-OcKn_-3lEO42DmkisB3B7vrq2j1Di2adD2q5HcDeeDaZzOn69uuHKV4n0_niM75dxuPfIJb1Yw
link.rule.ids 314,780,784,12056,21388,27924,27925,31719,33744,41081,41523,42150,42592,43310,43805,52111,52234,73745,74302
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7R7QEuiHdDafEB9QCNSGLHuzlVpWq1he1qRXdRb5bjBwKpSWm2Qttfz0weG1UFjonkOPI3tj_PfDMGeDeSxuNGZcIoj_NQ-FiGOuVJaNNcczSQzDnyQ55N5XghPl-kF602p2plld2aWC_UtjTkI_84whMTH_I4Pbj6FdKlURRcbW_Q2IBNKpyeDmDz0_F09nW9FON2V9ePGiYCp72Iu7BmnTsXR5ScTLFgSuS5vbMxbXhdkkxSVzhSvrni4m8c9F78tN6WTp7A45ZPssPGAJ7CA1c8g71ZU5B6tc_mfX5Vtc_22KwvVb16Du6QnV-i8bDaMei1cQxJLCOdMqVU0etrkjpfYhenxc9atlUwXVh88jfkaGOlZ6QVqV9Oyt_s24_KkBBsxdYetxewODmeH43D9uKF0IhELEODpEY665HMiZHUQzxDW2sMTlWkc96LxHGK9vHUZHmC0GrveSa0lSKySE9i_hIGRVm4LWCRc85nUgubW6FzozNsmDo5MjyKjI0DeN-Nurpq6muovpIyQaQQIkUQqdsAthAXpb_j-qcW5wlFXRFhgawsgN07YK0_RvUGZRbzALY79FQ7TSu1NqoAXjWA9u2wc4H_GMCHDuG-3T__8PV_e3kLD8fzs4manE6_bMOjxj1NcrY3MFhe37gd5DfLfLe14j9FWfQm
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT9RAEJ_IkRhfjPhFQXAfDA9KQ9vd7l2fDAoXULxchDO8bbb7QSShRXrEHH-9M_24hqA-XpPtXvqbzvw685tZgHcjaTwGKhNGeZyHwscy1ClPQpvmmqOBZM5RHvLbRB7NxJfz9LwdKVS1ssrOJ9aO2paGcuR7I_xi4kMep3u-VUVMD8Yfr3-FdIAUFVrb0zRWYBWDYpQMYPXT4WT6femWMfTVs6SGiUAXIOKuxFn30cURNSpTXZiaeu7uBakVr0uSTOoKn5pvjrv4Gx99UEutQ9T4GTxtuSXbb4xhDR654jnsTJvh1Itddtb3WlW7bIdN-7HVixfg9tnpFRoSq5OEXhvHkNAy0ixTexVdviHZ8xVucVxc1hKugunC4i9_S0k3VnpGupH64kn5m_34WRkShS3YMvv2Embjw7PPR2F7CENoRCLmoUGCI531SOzESOohfk9bawy-tkjtvBeJ41T546nJ8gRh1t7zTGgrRWSRqsT8FQyKsnDrwCLnnM-kFja3QudGZ7gwdXJkeBQZGwfwvnvq6rqZtaH6qcoEkUKIFEGk7gJYR1yUvkBfqGanCVVgEWGBDC2A7XtgLW9GswdlFvMANjv0VPvKVmppYAG8bgDt1-HmaFNRAB86hPt1__yHG__d5S08RgNWJ8eTr5vwpMlUk7LtDQzmN7duC6nOPN9ujfgP4TH4Uw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Smart+Interface+for+Reliable+Intradermal+Injection+and+Infusion+of+High+and+Low+Viscosity+Solutions&rft.jtitle=Pharmaceutical+research&rft.au=Vosseler%2C+Michael&rft.au=Jugl%2C+Michael&rft.au=Zengerle%2C+Roland&rft.date=2011-03-01&rft.pub=Boston+%3A+Springer+US&rft.issn=0724-8741&rft.eissn=1573-904X&rft.volume=28&rft.issue=3&rft.spage=647&rft.epage=661&rft_id=info:doi/10.1007%2Fs11095-010-0319-z&rft.externalDocID=US201301944615
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0724-8741&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0724-8741&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0724-8741&client=summon