Pharmacophore-Model-Based Virtual-Screening Approaches Identified Novel Natural Molecular Candidates for Treating Human Neuroblastoma

• Published in: Current Issues in Molecular Biology Vol. 44; no. 10; pp. 4838 - 4858
• Main Authors: Opo, F A Dain Md, Alkarim, Saleh, Alrefaei, Ghadeer I., Molla, Mohammad Habibur Rahman, Alsubhi, Nouf H., Alzahrani, Faisal, Ahammad, Foysal
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.10.2022; MDPI
• Subjects: Brd4; Health aspects; Lead compounds; molecular docking; Molecular dynamics; Mortality; MYCN; Neuroblastoma; pharmacophore model; Physiological aspects; Protein binding; Proteins; Saudi Arabia; side effects; Taiwan; Saudi Arabia; Taiwan

The mortality of cancer patients with neuroblastoma is increasing due to the limited availability of specific treatment options. Few drug candidates for combating neuroblastoma have been developed, and identifying novel therapeutic candidates against the disease is an urgent issue. It has been found...