MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses
The myocyte enhancer factor (MEF2) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number and reducing dendritic spines. Myocyte enhancer factor 2 C (MEF2C) is regarded as modulator of amyloid-protein precursor (APP) proteolytic pr...
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Published in | Oncotarget Vol. 7; no. 26; pp. 39136 - 39142 |
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Abstract | The myocyte enhancer factor (MEF2) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number and reducing dendritic spines. Myocyte enhancer factor 2 C (MEF2C) is regarded as modulator of amyloid-protein precursor (APP) proteolytic processing, in which amyloid-β (Aβ) is produced. A common single nucleotide polymorphism (SNP, rs190982) in MEF2C gene was identified to be related to late-onset Alzheimer's disease (LOAD) in Caucasians in a large meta-analysis of genome-wide association studies (GWAS). Here, we recruited unrelated 984 LOAD patients and 1348 healthy controls matched for gender and age to ascertain whether the rs190982 polymorphism is related to LOAD in Han Chinese. No difference in the genotype and allele distributions of the MEF2C rs190982 polymorphism was found between LOAD cases and healthy controls (genotype: P = 0.861; allele: P = 0.862), even after stratification for APOE ε4 allele as well as statistical adjustment for age, gender and APOE ε4 status. Furthermore, the meta-analysis in 4089 Chinese individuals did not detect the association of rs190982 within MEF2C with the risk for LOAD (OR = 1.03, 95%CI = 0.90-1.18). Overall, the current evidence did not support the relation between rs190982 polymorphism within MEF2C and the LOAD risk in Northern Han Chinese. |
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AbstractList | The myocyte enhancer factor (MEF2) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number and reducing dendritic spines. Myocyte enhancer factor 2 C (MEF2C) is regarded as modulator of amyloid-protein precursor (APP) proteolytic processing, in which amyloid-β (Aβ) is produced. A common single nucleotide polymorphism (SNP, rs190982) in MEF2C gene was identified to be related to late-onset Alzheimer's disease (LOAD) in Caucasians in a large meta-analysis of genome-wide association studies (GWAS). Here, we recruited unrelated 984 LOAD patients and 1348 healthy controls matched for gender and age to ascertain whether the rs190982 polymorphism is related to LOAD in Han Chinese. No difference in the genotype and allele distributions of the MEF2C rs190982 polymorphism was found between LOAD cases and healthy controls (genotype: P = 0.861; allele: P = 0.862), even after stratification for APOE ε4 allele as well as statistical adjustment for age, gender and APOE ε4 status. Furthermore, the meta-analysis in 4089 Chinese individuals did not detect the association of rs190982 within MEF2C with the risk for LOAD (OR = 1.03, 95%CI = 0.90-1.18). Overall, the current evidence did not support the relation between rs190982 polymorphism within MEF2C and the LOAD risk in Northern Han Chinese. The myocyte enhancer factor ( MEF2 ) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number and reducing dendritic spines. Myocyte enhancer factor 2 C ( MEF2C ) is regarded as modulator of amyloid-protein precursor (APP) proteolytic processing, in which amyloid-β (Aβ) is produced. A common single nucleotide polymorphism (SNP, rs190982) in MEF2C gene was identified to be related to late-onset Alzheimer's disease (LOAD) in Caucasians in a large meta-analysis of genome-wide association studies (GWAS). Here, we recruited unrelated 984 LOAD patients and 1348 healthy controls matched for gender and age to ascertain whether the rs190982 polymorphism is related to LOAD in Han Chinese. No difference in the genotype and allele distributions of the MEF2C rs190982 polymorphism was found between LOAD cases and healthy controls (genotype: P = 0.861; allele: P = 0.862), even after stratification for APOE ε4 allele as well as statistical adjustment for age, gender and APOE ε4 status. Furthermore, the meta-analysis in 4089 Chinese individuals did not detect the association of rs190982 within MEF2C with the risk for LOAD (OR = 1.03, 95%CI = 0.90-1.18). Overall, the current evidence did not support the relation between rs190982 polymorphism within MEF2C and the LOAD risk in Northern Han Chinese. |
Author | Wang, Hui-Fu Tan, Meng-Shan Wang, Zi-Xuan Kong, Ling-Li Tan, Lan Jiang, Teng Zhang, Wei Yu, Jin-Tai Zheng, Zhan-Jie Tang, Shan-Shan Tan, Lin Tan, Chen-Chen |
AuthorAffiliation | 3 Department of Geriatric, Qingdao Mental Health Center, Qingdao, PR China 1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China 2 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China 5 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, PR China 4 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, PR China |
AuthorAffiliation_xml | – name: 4 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, PR China – name: 1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China – name: 5 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, PR China – name: 3 Department of Geriatric, Qingdao Mental Health Center, Qingdao, PR China – name: 2 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China |
Author_xml | – sequence: 1 givenname: Shan-Shan surname: Tang fullname: Tang, Shan-Shan organization: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China – sequence: 2 givenname: Hui-Fu surname: Wang fullname: Wang, Hui-Fu organization: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China – sequence: 3 givenname: Wei surname: Zhang fullname: Zhang, Wei organization: Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China – sequence: 4 givenname: Ling-Li surname: Kong fullname: Kong, Ling-Li organization: Department of Geriatric, Qingdao Mental Health Center, Qingdao, PR China – sequence: 5 givenname: Zhan-Jie surname: Zheng fullname: Zheng, Zhan-Jie organization: Department of Geriatric, Qingdao Mental Health Center, Qingdao, PR China – sequence: 6 givenname: Meng-Shan surname: Tan fullname: Tan, Meng-Shan organization: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China – sequence: 7 givenname: Chen-Chen surname: Tan fullname: Tan, Chen-Chen organization: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China – sequence: 8 givenname: Zi-Xuan surname: Wang fullname: Wang, Zi-Xuan organization: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China – sequence: 9 givenname: Lin surname: Tan fullname: Tan, Lin organization: College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, PR China – sequence: 10 givenname: Teng surname: Jiang fullname: Jiang, Teng organization: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, PR China – sequence: 11 givenname: Jin-Tai surname: Yu fullname: Yu, Jin-Tai organization: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China – sequence: 12 givenname: Lan surname: Tan fullname: Tan, Lan organization: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China |
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Keywords | meta-analysis MEF2C Gerotarget Alzheimer’s disease rs190982 association study |
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Snippet | The myocyte enhancer factor (MEF2) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number... The myocyte enhancer factor ( MEF2 ) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse... |
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SubjectTerms | Aged Alleles Alzheimer Disease - genetics Alzheimer Disease - metabolism Animals Apolipoproteins E - genetics Asian Continental Ancestry Group Case-Control Studies China Female Genetic Association Studies Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male MEF2 Transcription Factors - genetics Mice Mutation Polymorphism, Single Nucleotide Regression Analysis Reproducibility of Results Research Paper: Gerotarget (Focus on Aging) |
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Title | MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses |
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