Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: a surrogate marker for NK-cell clonality

• Published in: Oncotarget Vol. 6; no. 40; pp. 42938 - 42951
• Main Authors: Bárcena, Paloma, Jara-Acevedo, María, Tabernero, María Dolores, López, Antonio, Sánchez, María Luz, García-Montero, Andrés C., Muñoz-García, Noemí, Vidriales, María Belén, Paiva, Artur, Lecrevisse, Quentin, Lima, Margarida, Langerak, Anton W., Böttcher, Sebastian, van Dongen, Jacques J.M., Orfao, Alberto, Almeida, Julia
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 15.12.2015
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - analysis; Chronic Disease; Clone Cells - pathology; Cluster Analysis; Female; Flow Cytometry - methods; Humans; Immunophenotyping; Killer Cells, Natural - pathology; Lymphoproliferative Disorders - diagnosis; Middle Aged; Phenotype; Receptors, Androgen - analysis; Research Paper; natural killer cells; NK cells; clonality; CLPD-NK; immunophenotype

Currently, the lack of a universal and specific marker of clonality hampers the diagnosis and classification of chronic expansions of natural killer (NK) cells. Here we investigated the utility of flow cytometric detection of aberrant/altered NK-cell phenotypes as a surrogate marker for clonality, i...