Pulmonary Neuroendocrine Cells Secrete γ-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models

• Published in: American journal of respiratory cell and molecular biology Vol. 60; no. 6; pp. 687 - 694
• Main Authors: Barrios, Juliana, Kho, Alvin T., Aven, Linh, Mitchel, Jennifer A., Park, Jin-Ah, Randell, Scott H., Miller, Lisa A., Tantisira, Kelan G., Ai, Xingbin
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.06.2019
• Subjects: Acute Lung Injury - pathology; Animal models; Animals; Asthma; Asthma - pathology; Bronchi - pathology; Cell culture; Cell proliferation; Chronic obstructive pulmonary disease; Disease Models, Animal; Epithelial cells; Epithelial Cells - metabolism; Epithelium; gamma-Aminobutyric Acid - metabolism; Gene expression; Goblet Cells - pathology; Health care; Humans; Hyperplasia; Hypersensitivity; Inflammation; Interleukin 13; Interleukin-13 - metabolism; Lung - pathology; Lung diseases; Lungs; Macaca mulatta; Medicine; Morbidity; Mucus - metabolism; Neonates; Nervous system; Neuroendocrine Cells - metabolism; Original Research; Physiology; Primates; Receptors, GABA - metabolism; Respiratory tract; Signal Transduction; Smooth muscle; Studies; United States > US; Massachusetts; California; pulmonary neuroendocrine cell; asthma; goblet cell hyperplasia; mucus overproduction; γ-aminobutyric acid

Mucus overproduction is a major contributor to morbidity and mortality in asthma. Mucus overproduction is induced by orchestrated actions of multiple factors that include inflammatory cytokines and γ-aminobutyric acid (GABA). GABA is produced only by pulmonary neuroendocrine cells (PNECs) in the mou...