Immune-Enhancing Effects of Lactobacillus plantarum 200655 Isolated from Korean Kimchi in a Cyclophosphamide-Induced Immunocompromised Mouse Model

• Published in: Journal of microbiology and biotechnology Vol. 31; no. 5; pp. 726 - 732
• Main Authors: Kim, Kyeong Jin, Paik, Hyun-Dong, Kim, Ji Yeon
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society for Microbiology and Biotechnology 28.05.2021; 한국미생물·생명공학회
• Subjects: Alanine Transaminase - blood; Animals; Cyclophosphamide - pharmacology; Cytokines - metabolism; Disease Models, Animal; Fermented Foods - microbiology; Immunocompromised Host - drug effects; Immunocompromised Host - immunology; Killer Cells, Natural - drug effects; Killer Cells, Natural - immunology; Lactobacillus plantarum - isolation & purification; MAP Kinase Signaling System - drug effects; Mice; Mice, Inbred ICR; Probiotics - administration & dosage; Probiotics - pharmacology; Republic of Korea; Research article; Spleen - drug effects; Spleen - immunology; 생물학; Republic of Korea; immune enhancement; Cyclophosphamide; Lactobacillus plantarum; splenocytes; MAPK/ERK signaling pathway

In this study, we evaluated the immune-enhancing activity of kimchi-derived 200655 on immune suppression by cyclophosphamide (CP) in ICR mice. Animals were fed distilled water or 1×10 colony-forming unit/kg B.W. 200655 or GG as a positive control for 14 days. An in vivo model of immunosuppression wa...