Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway

• Published in: Toxicology in vitro Vol. 62; p. 104715
• Main Authors: Jiang, Ting, Cheng, Hui, Su, Jingjing, Wang, Xuncui, Wang, Qiaoxue, Chu, Jun, Li, Qinglin
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.02.2020; Elsevier Science Ltd
• Subjects: Antioxidants; Apoptosis; Cell death; Ferroptosis; Gastrodin; Glutamate; Heme oxygenase (decyclizing); Hippocampus; Ion concentration; Iron; Neurodegenerative diseases; Neurotoxicity; Nrf2/HO-1 pathway; Nuclear transport; Pretreatment; Signal transduction; Signaling; Translocation; Ferroptosis; HO-1; MDA; DFO; MTT; PTGS2; GPX; DMEM; LDH; SD; min; Nrf2; FBS; Gastrodin; Wnt; GSH; GPX4; Neurodegenerative diseases; Fig; h; DAPI; SOD; ACSL4; EDTA; Glutamate; s; Nrf2/HO-1 pathway; ROS; ICP-MS

Gastrodin (GAS) is a component of Gastrodia elata Blume, with strong antioxidant activity in neurodegenerative diseases. Ferroptosis is similar to glutamate-induced cell death. This study was designed to explore the protective effects of GAS against glutamate-induced neurotoxicity in mice hippocampa...