Oncogenic Function and Early Detection Potential of miRNA-10b in Oral Cancer as Identified by microRNA Profiling

• Published in: Cancer prevention research (Philadelphia, Pa.) Vol. 5; no. 4; pp. 665 - 674
• Main Authors: Lu, Ya-Ching, Chen, Yin-Ju, Wang, Hung-Ming, Tsai, Chi-Ying, Chen, Wen-Ho, Huang, Yu-Chen, Fan, Kang-Hsing, Tsai, Chi-Neu, Huang, Shiang-Fu, Kang, Chung-Jan, Chang, Joseph Tung-Chieh, Cheng, Ann-Joy
• Format: Journal Article
• Language: English
• Published: United States 01.04.2012
• Subjects: Adult; Aged; Animals; Area Under Curve; Biomarkers, Tumor - metabolism; Cell Movement; Cluster Analysis; Collagen - chemistry; Drug Combinations; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Keratinocytes - cytology; Laminin - chemistry; Male; Mice; MicroRNAs - biosynthesis; MicroRNAs - metabolism; Middle Aged; Mouth Neoplasms - metabolism; Neoplasm Transplantation; Proteoglycans - chemistry; Up-Regulation

The miRNA participates in a variety of biologic processes, and dysregulation of miRNA is associated with malignant transformation. In this study, we determined specific profile of miRNA associated with oral cancer by using miRNA array screening method. There were 23 miRNAs found with considerably di...