Evaluating the Diagnostic Potential of Combined Salivary and Skin Biomarkers in Parkinson’s Disease

• Published in: International journal of molecular sciences Vol. 25; no. 9; p. 4823
• Main Authors: Costanzo, Matteo, Galosi, Eleonora, De Bartolo, Maria Ilenia, Gallo, Gaetano, Leodori, Giorgio, Belvisi, Daniele, Conte, Antonella, Fabbrini, Giovanni, Truini, Andrea, Berardelli, Alfredo, Vivacqua, Giorgio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Age; Aged; alpha-Synuclein - analysis; alpha-Synuclein - metabolism; Analysis; Biological markers; Biomarkers; Biomarkers - metabolism; Biopsy; Case-Control Studies; Disease; Enzyme-linked immunosorbent assay; Female; Gender; Humans; Male; Medical research; Medicine, Experimental; Middle Aged; Oligomers; Parkinson Disease - diagnosis; Parkinson Disease - metabolism; Phosphorylation; Regression analysis; Saliva - metabolism; Skin; Skin - metabolism; Skin - pathology; alpha-synuclein; synucleinopathies; biomarkers; Parkinson’s disease
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25094823

Oligomeric alpha-synuclein (α-syn) in saliva and phosphorylated α-syn deposits in the skin have emerged as promising diagnostic biomarkers for Parkinson’s disease (PD). This study aimed to assess and compare the diagnostic value of these biomarkers in discriminating between 38 PD patients and 24 hea...