Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells

• Published in: The Journal of immunology (1950) Vol. 201; no. 3; pp. 971 - 981
• Main Authors: Porichis, Filippos, Hart, Meghan G, Massa, Alexandra, Everett, Holly L, Morou, Antigoni, Richard, Jonathan, Brassard, Nathalie, Veillette, Maxime, Hassan, Muska, Ly, Ngoc Le, Routy, Jean-Pierre, Freeman, Gordon J, Dubé, Mathieu, Finzi, Andrés, Kaufmann, Daniel E
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 01.08.2018
• Subjects: Adaptive immunity; Anti-Retroviral Agents - pharmacology; Antiretroviral therapy; Cancer; CD4 antigen; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; Cell Line, Tumor; Cohort Studies; Cytokines; Degranulation; HIV; HIV Infections - drug therapy; HIV Infections - immunology; HIV-1 - drug effects; HIV-1 - immunology; Human immunodeficiency virus; Humans; Immune checkpoint; Immunomodulation; Infections; Innate immunity; Interferon-gamma - immunology; Interleukin 10; Interleukin 12; Interleukin 2; Interleukin-10 - immunology; Interleukin-2 - immunology; K562 Cells; Killer Cells, Natural - drug effects; Killer Cells, Natural - immunology; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - virology; Lymphocytes; Lymphocytes T; Natural killer cells; PD-1 protein; Peripheral blood mononuclear cells; Programmed Cell Death 1 Receptor - immunology; Viral Load - drug effects; Viral Load - immunology; Viremia; γ-Interferon

Immune exhaustion is an important feature of chronic infections, such as HIV, and a barrier to effective immunity against cancer. This dysfunction is in part controlled by inhibitory immune checkpoints. Blockade of the PD-1 or IL-10 pathways can reinvigorate HIV-specific CD4 T cell function in vitro...