Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

• Published in: Cell Vol. 151; no. 2; pp. 414 - 426
• Main Authors: Teperino, Raffaele, Amann, Sabine, Bayer, Martina, McGee, Sean L., Loipetzberger, Andrea, Connor, Timothy, Jaeger, Carsten, Kammerer, Bernd, Winter, Lilli, Wiche, Gerhard, Dalgaard, Kevin, Selvaraj, Madhan, Gaster, Michael, Lee-Young, Robert S., Febbraio, Mark A., Knauf, Claude, Cani, Patrice D., Aberger, Fritz, Penninger, Josef M., Pospisilik, J. Andrew, Esterbauer, Harald
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.10.2012
• Subjects: Adipocytes - metabolism; Adipose Tissue, Brown - metabolism; agonistic behavior; agonists; Animals; brown adipose tissue; Cell Line; Cells, Cultured; Cilia - metabolism; cyclopamine; diabetes; Diabetes Mellitus - metabolism; glucose; Glycolysis; Hedgehog Proteins - metabolism; Humans; metabolism; Mice; Muscle Cells - metabolism; muscles; Neoplasms - metabolism; obesity; Obesity - metabolism; Protein Kinases - metabolism; Receptors, G-Protein-Coupled - metabolism; Signal Transduction; signals; Smoothened Receptor

Diabetes, obesity, and cancer affect upward of 15% of the world’s population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling with altered metabolic state. Exactly which genetic factors define stable metabolic set points in vivo remains poorly understood. Here, we sh...