Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

Diabetes, obesity, and cancer affect upward of 15% of the world’s population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling with altered metabolic state. Exactly which genetic factors define stable metabolic set points in vivo remains poorly understood. Here, we sh...

Full description

Saved in:
Bibliographic Details
Published inCell Vol. 151; no. 2; pp. 414 - 426
Main Authors Teperino, Raffaele, Amann, Sabine, Bayer, Martina, McGee, Sean L., Loipetzberger, Andrea, Connor, Timothy, Jaeger, Carsten, Kammerer, Bernd, Winter, Lilli, Wiche, Gerhard, Dalgaard, Kevin, Selvaraj, Madhan, Gaster, Michael, Lee-Young, Robert S., Febbraio, Mark A., Knauf, Claude, Cani, Patrice D., Aberger, Fritz, Penninger, Josef M., Pospisilik, J. Andrew, Esterbauer, Harald
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 12.10.2012
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Diabetes, obesity, and cancer affect upward of 15% of the world’s population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling with altered metabolic state. Exactly which genetic factors define stable metabolic set points in vivo remains poorly understood. Here, we show that hedgehog signaling rewires cellular metabolism. We identify a cilium-dependent Smo-Ca2+-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility. We show that Smo modulators can uncouple the Smo-Ampk axis from canonical signaling and identify cyclopamine as one of a new class of “selective partial agonists,” capable of concomitant inhibition of canonical and activation of noncanonical hedgehog signaling. Intriguingly, activation of the Smo-Ampk axis in vivo drives robust insulin-independent glucose uptake in muscle and brown adipose tissue. These data identify multiple noncanonical endpoints that are pivotal for rational design of hedgehog modulators and provide a new therapeutic avenue for obesity and diabetes. [Display omitted] ► Hedgehog signaling rapidly reprograms energy metabolism ► Smoothened activates a rapid primary cilium-dependent Smo-Ampk axis ► Cyclopamine and GDC-0449 uncouple canonical and noncanonical Smo signaling ► Smoothened drives insulin-independent glucose uptake in muscle and BAT in vivo A new hedgehog-induced regulatory circuit, mediated by a rapid noncanonical Smo-Ca2+-Ampk signaling arm, rewires cellular metabolism within minutes, prompting glucose uptake in muscle and brown fat in vivo.
AbstractList Diabetes, obesity, and cancer affect upward of 15% of the world's population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling with altered metabolic state. Exactly which genetic factors define stable metabolic set points in vivo remains poorly understood. Here, we show that hedgehog signaling rewires cellular metabolism. We identify a cilium-dependent Smo-Ca(2+)-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility. We show that Smo modulators can uncouple the Smo-Ampk axis from canonical signaling and identify cyclopamine as one of a new class of "selective partial agonists," capable of concomitant inhibition of canonical and activation of noncanonical hedgehog signaling. Intriguingly, activation of the Smo-Ampk axis in vivo drives robust insulin-independent glucose uptake in muscle and brown adipose tissue. These data identify multiple noncanonical endpoints that are pivotal for rational design of hedgehog modulators and provide a new therapeutic avenue for obesity and diabetes.
Diabetes, obesity, and cancer affect upward of 15% of the world’s population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling with altered metabolic state. Exactly which genetic factors define stable metabolic set points in vivo remains poorly understood. Here, we show that hedgehog signaling rewires cellular metabolism. We identify a cilium-dependent Smo-Ca²⁺-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility. We show that Smo modulators can uncouple the Smo-Ampk axis from canonical signaling and identify cyclopamine as one of a new class of “selective partial agonists,” capable of concomitant inhibition of canonical and activation of noncanonical hedgehog signaling. Intriguingly, activation of the Smo-Ampk axis in vivo drives robust insulin-independent glucose uptake in muscle and brown adipose tissue. These data identify multiple noncanonical endpoints that are pivotal for rational design of hedgehog modulators and provide a new therapeutic avenue for obesity and diabetes.
Diabetes, obesity, and cancer affect upward of 15% of the world’s population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling with altered metabolic state. Exactly which genetic factors define stable metabolic set points in vivo remains poorly understood. Here, we show that hedgehog signaling rewires cellular metabolism. We identify a cilium-dependent Smo-Ca2+-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility. We show that Smo modulators can uncouple the Smo-Ampk axis from canonical signaling and identify cyclopamine as one of a new class of “selective partial agonists,” capable of concomitant inhibition of canonical and activation of noncanonical hedgehog signaling. Intriguingly, activation of the Smo-Ampk axis in vivo drives robust insulin-independent glucose uptake in muscle and brown adipose tissue. These data identify multiple noncanonical endpoints that are pivotal for rational design of hedgehog modulators and provide a new therapeutic avenue for obesity and diabetes. [Display omitted] ► Hedgehog signaling rapidly reprograms energy metabolism ► Smoothened activates a rapid primary cilium-dependent Smo-Ampk axis ► Cyclopamine and GDC-0449 uncouple canonical and noncanonical Smo signaling ► Smoothened drives insulin-independent glucose uptake in muscle and BAT in vivo A new hedgehog-induced regulatory circuit, mediated by a rapid noncanonical Smo-Ca2+-Ampk signaling arm, rewires cellular metabolism within minutes, prompting glucose uptake in muscle and brown fat in vivo.
Author Lee-Young, Robert S.
Cani, Patrice D.
Febbraio, Mark A.
Knauf, Claude
Selvaraj, Madhan
Connor, Timothy
Esterbauer, Harald
Gaster, Michael
Bayer, Martina
Winter, Lilli
McGee, Sean L.
Kammerer, Bernd
Teperino, Raffaele
Loipetzberger, Andrea
Pospisilik, J. Andrew
Jaeger, Carsten
Dalgaard, Kevin
Wiche, Gerhard
Aberger, Fritz
Amann, Sabine
Penninger, Josef M.
Author_xml – sequence: 1
  givenname: Raffaele
  surname: Teperino
  fullname: Teperino, Raffaele
  organization: Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D-79108 Freiburg, Germany
– sequence: 2
  givenname: Sabine
  surname: Amann
  fullname: Amann, Sabine
  organization: Department of Laboratory Medicine, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
– sequence: 3
  givenname: Martina
  surname: Bayer
  fullname: Bayer, Martina
  organization: Department of Laboratory Medicine, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
– sequence: 4
  givenname: Sean L.
  surname: McGee
  fullname: McGee, Sean L.
  organization: Metabolic Remodeling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, 75 Pigdons Road, Geelong, Victoria 3220, Australia
– sequence: 5
  givenname: Andrea
  surname: Loipetzberger
  fullname: Loipetzberger, Andrea
  organization: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, A-5020 Salzburg, Austria
– sequence: 6
  givenname: Timothy
  surname: Connor
  fullname: Connor, Timothy
  organization: Metabolic Remodeling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, 75 Pigdons Road, Geelong, Victoria 3220, Australia
– sequence: 7
  givenname: Carsten
  surname: Jaeger
  fullname: Jaeger, Carsten
  organization: Metabolomics Core, Center for Biological Systems Analysis (ZBSA), Habsburgerstrasse 49, D-79104 Freiburg, Germany
– sequence: 8
  givenname: Bernd
  surname: Kammerer
  fullname: Kammerer, Bernd
  organization: Metabolomics Core, Center for Biological Systems Analysis (ZBSA), Habsburgerstrasse 49, D-79104 Freiburg, Germany
– sequence: 9
  givenname: Lilli
  surname: Winter
  fullname: Winter, Lilli
  organization: Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, Dr. Bohr-Gasse 9, A-1030 Vienna, Austria
– sequence: 10
  givenname: Gerhard
  surname: Wiche
  fullname: Wiche, Gerhard
  organization: Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, Dr. Bohr-Gasse 9, A-1030 Vienna, Austria
– sequence: 11
  givenname: Kevin
  surname: Dalgaard
  fullname: Dalgaard, Kevin
  organization: Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D-79108 Freiburg, Germany
– sequence: 12
  givenname: Madhan
  surname: Selvaraj
  fullname: Selvaraj, Madhan
  organization: Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D-79108 Freiburg, Germany
– sequence: 13
  givenname: Michael
  surname: Gaster
  fullname: Gaster, Michael
  organization: Departments of Pathology and Endocrinology, Odense University Hospital, J.B. Winsløwsvej 25, DK-5000 Odense, Denmark
– sequence: 14
  givenname: Robert S.
  surname: Lee-Young
  fullname: Lee-Young, Robert S.
  organization: Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, 3004, Australia
– sequence: 15
  givenname: Mark A.
  surname: Febbraio
  fullname: Febbraio, Mark A.
  organization: Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, 3004, Australia
– sequence: 16
  givenname: Claude
  surname: Knauf
  fullname: Knauf, Claude
  organization: INSERM U1048, Team 3, Institut de Medecine Moleculaire de Rangueil, Paul Sabatier University, Bat. L4, IFR150, CHU Rangueil, BP 84225, F-31432 Toulouse Cedex 4, France
– sequence: 17
  givenname: Patrice D.
  surname: Cani
  fullname: Cani, Patrice D.
  organization: Université Catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Av. E. Mounier 73, B-1200 Brussels, Belgium
– sequence: 18
  givenname: Fritz
  surname: Aberger
  fullname: Aberger, Fritz
  organization: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, A-5020 Salzburg, Austria
– sequence: 19
  givenname: Josef M.
  surname: Penninger
  fullname: Penninger, Josef M.
  organization: Institute of Molecular Biotechnology of the Austrian Academy of Science, Dr. Bohrgasse 3, A-1030 Vienna, Austria
– sequence: 20
  givenname: J. Andrew
  surname: Pospisilik
  fullname: Pospisilik, J. Andrew
  email: pospisilik@ie-freiburg.mpg.de
  organization: Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D-79108 Freiburg, Germany
– sequence: 21
  givenname: Harald
  surname: Esterbauer
  fullname: Esterbauer, Harald
  email: harald.esterbauer@meduniwien.ac.at
  organization: Department of Laboratory Medicine, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23063129$$D View this record in MEDLINE/PubMed
BookMark eNp9kMFu1TAQRS1URF8LP8ACvGSTMOMkTiyxKaWlSK1aCSqWlu1Mgh95cWsnRfx9E73CsqtZ3HOvRueIHYxhJMbeIuQIKD9uc0fDkAtAkYPKQeALtkFQdVZiLQ7YBkCJrJF1eciOUtoCQFNV1St2KAqQBQq1YdcX1Pb0K_T8xsTJm4Gf9GH0ace_RP9Aif800c6xzwb_m_gVTcaGYY39yK_m5AbiZmz55xj-jPzcTK_Zy84Mid483WN2e3724_Qiu7z--u305DJzpSinzJSNKZoOHTa2bpzD0rpK1cp0JJvOFqq2LQjZosUSDZERoCq05FSpoLZUHLMP-927GO5nSpPe-bTqMCOFOWlEFEUpaqwWVOxRF0NKkTp9F_3OxL8aQa8i9VavTb2K1KD0InIpvXvan-2O2v-Vf-YW4P0e6EzQpo8-6dvvy4JcLIOspFyIT3uCFg8PnqJOztPoqPWR3KTb4J_74BEbF457
CitedBy_id crossref_primary_10_1007_s13671_014_0073_2
crossref_primary_10_3390_ijms19082423
crossref_primary_10_3390_life13040996
crossref_primary_10_2139_ssrn_3205404
crossref_primary_10_1016_j_metabol_2020_154396
crossref_primary_10_1155_2016_2365609
crossref_primary_10_4161_15384101_2014_952973
crossref_primary_10_1083_jcb_201910087
crossref_primary_10_1101_cshperspect_a028217
crossref_primary_10_1007_s00125_017_4223_5
crossref_primary_10_1016_j_bioorg_2023_106488
crossref_primary_10_1111_cas_13022
crossref_primary_10_1242_bio_013425
crossref_primary_10_3389_fcell_2022_944760
crossref_primary_10_1051_medsci_20132910012
crossref_primary_10_1073_pnas_2105367118
crossref_primary_10_1139_bcb_2022_0345
crossref_primary_10_1016_j_jcmgh_2022_12_008
crossref_primary_10_3390_cancers11040449
crossref_primary_10_2217_fon_2016_0296
crossref_primary_10_1007_s12325_017_0556_1
crossref_primary_10_1016_j_devcel_2013_07_015
crossref_primary_10_1002_bies_201400157
crossref_primary_10_1007_s11515_015_1349_z
crossref_primary_10_1016_j_phrs_2019_01_014
crossref_primary_10_1016_j_ejmech_2016_05_062
crossref_primary_10_2217_fon_14_50
crossref_primary_10_1158_1078_0432_CCR_13_1710
crossref_primary_10_1186_s13148_015_0048_6
crossref_primary_10_1073_pnas_1416463112
crossref_primary_10_1002_cmdc_201300217
crossref_primary_10_1111_1759_7714_15150
crossref_primary_10_1016_j_biochi_2013_02_013
crossref_primary_10_1155_2014_873010
crossref_primary_10_1074_jbc_M115_665232
crossref_primary_10_1038_nrm3598
crossref_primary_10_1016_j_cell_2014_04_043
crossref_primary_10_1074_jbc_RA119_007883
crossref_primary_10_1007_s11684_015_0382_2
crossref_primary_10_1016_j_jhep_2017_06_008
crossref_primary_10_1016_j_mce_2020_110970
crossref_primary_10_1039_C5NP00153F
crossref_primary_10_18632_oncotarget_1789
crossref_primary_10_1002_ptr_7667
crossref_primary_10_1371_journal_pgen_1011067
crossref_primary_10_3390_cells10040768
crossref_primary_10_1016_j_molmed_2015_07_003
crossref_primary_10_1016_j_cellsig_2022_110488
crossref_primary_10_1016_j_tips_2014_03_002
crossref_primary_10_3389_fcell_2022_1083372
crossref_primary_10_3389_fncel_2020_00098
crossref_primary_10_1016_j_phrs_2022_106194
crossref_primary_10_1371_journal_pgen_1003955
crossref_primary_10_15252_embr_201745144
crossref_primary_10_4155_fmc_2018_0497
crossref_primary_10_1016_j_biocel_2024_106518
crossref_primary_10_1016_j_celrep_2018_08_064
crossref_primary_10_1016_j_molmet_2021_101172
crossref_primary_10_1242_dev_166892
crossref_primary_10_1186_s12964_020_00591_0
crossref_primary_10_3389_fonc_2023_1264083
crossref_primary_10_1186_s12915_017_0442_y
crossref_primary_10_3390_ijms21020412
crossref_primary_10_1016_j_molmed_2016_05_006
crossref_primary_10_1016_j_jhep_2017_10_017
crossref_primary_10_1186_1742_4933_10_10
crossref_primary_10_3390_cancers13143410
crossref_primary_10_1002_cmdc_201300358
crossref_primary_10_1038_ncomms5355
crossref_primary_10_1038_s41467_023_37928_5
crossref_primary_10_15252_embr_202154025
crossref_primary_10_1074_jbc_RA118_004411
crossref_primary_10_1185_03007995_2015_1018988
crossref_primary_10_1038_s41598_021_88434_x
crossref_primary_10_1007_s12170_013_0372_3
crossref_primary_10_1126_science_1248078
crossref_primary_10_3389_fphys_2021_769367
crossref_primary_10_3390_jdb5040011
crossref_primary_10_1371_journal_pbio_3001596
crossref_primary_10_1016_j_celrep_2020_108348
crossref_primary_10_1002_bies_202100183
crossref_primary_10_3389_fncel_2021_801704
crossref_primary_10_18632_oncotarget_4969
crossref_primary_10_1371_journal_pone_0133633
crossref_primary_10_3389_fimmu_2024_1375485
crossref_primary_10_3390_jdb10040050
crossref_primary_10_1038_s41467_022_35527_4
crossref_primary_10_1073_pnas_1602393113
crossref_primary_10_1159_000509156
crossref_primary_10_1038_s41598_018_37808_9
crossref_primary_10_3389_fonc_2015_00130
crossref_primary_10_1111_cpr_13358
crossref_primary_10_1016_j_lfs_2023_121704
crossref_primary_10_3389_fmolb_2021_807487
crossref_primary_10_1096_fj_14_267849
crossref_primary_10_3390_ijms22179436
crossref_primary_10_3390_cancers11040538
crossref_primary_10_1002_ciuz_201390020
crossref_primary_10_1007_s13105_023_00982_0
crossref_primary_10_1080_10409238_2018_1448752
crossref_primary_10_1002_chem_201701008
crossref_primary_10_3390_molecules28031022
crossref_primary_10_1007_s00018_014_1686_0
crossref_primary_10_1016_j_semcdb_2014_05_007
crossref_primary_10_1097_CCO_0b013e32835ff438
crossref_primary_10_3390_jpm12101648
crossref_primary_10_1016_j_cub_2014_12_021
crossref_primary_10_3390_ijms17060857
crossref_primary_10_3892_ijo_2022_5345
crossref_primary_10_3390_cells11142260
crossref_primary_10_1016_j_devcel_2015_10_015
crossref_primary_10_1016_j_devcel_2015_09_008
crossref_primary_10_1101_gad_249763_114
crossref_primary_10_1016_j_bbrc_2014_01_087
crossref_primary_10_1038_s42255_021_00488_3
crossref_primary_10_1111_nyas_12138
crossref_primary_10_1016_j_cbd_2023_101114
crossref_primary_10_1016_j_abb_2020_108743
crossref_primary_10_1371_journal_pbio_1001505
crossref_primary_10_1158_1078_0432_CCR_23_0666
crossref_primary_10_1007_s13555_020_00464_x
crossref_primary_10_1016_j_cmet_2020_08_015
crossref_primary_10_3389_fgene_2019_00556
crossref_primary_10_1177_1758834016653605
crossref_primary_10_1517_13543776_2015_1019864
crossref_primary_10_1038_ncb2655
crossref_primary_10_1007_s12195_020_00624_1
crossref_primary_10_1016_j_tips_2015_09_001
crossref_primary_10_1016_j_ypmed_2023_107576
crossref_primary_10_1186_1478_811X_12_11
crossref_primary_10_1016_j_bbcan_2015_06_003
crossref_primary_10_1016_j_ctrv_2019_04_005
crossref_primary_10_1038_s41467_024_45520_8
crossref_primary_10_1002_hep_27235
crossref_primary_10_1016_j_ydbio_2019_09_009
crossref_primary_10_1517_14728214_2014_914171
crossref_primary_10_1111_bph_13422
crossref_primary_10_1634_theoncologist_2016_0186
crossref_primary_10_1016_j_cell_2012_09_025
crossref_primary_10_1038_srep23479
crossref_primary_10_1038_aps_2013_64
crossref_primary_10_1080_10408398_2022_2148090
crossref_primary_10_1016_j_cmet_2014_11_019
crossref_primary_10_1111_eci_12675
crossref_primary_10_1073_pnas_1708321114
crossref_primary_10_3177_jnsv_66_41
crossref_primary_10_1016_j_bbabio_2017_01_013
crossref_primary_10_1016_j_plefa_2016_04_004
crossref_primary_10_1016_j_ccr_2012_12_011
crossref_primary_10_1016_j_isci_2021_103089
crossref_primary_10_1042_BJ20130457
crossref_primary_10_1111_dth_15191
crossref_primary_10_34133_research_0268
crossref_primary_10_1038_s41598_018_38345_1
crossref_primary_10_1016_j_mtbio_2022_100502
crossref_primary_10_1242_dev_186411
crossref_primary_10_1136_gutjnl_2018_316451
crossref_primary_10_3389_fimmu_2021_781923
crossref_primary_10_1016_j_jcmgh_2020_08_006
crossref_primary_10_1007_s11064_023_03864_5
crossref_primary_10_1155_2018_1287127
crossref_primary_10_1124_mol_112_084590
crossref_primary_10_1158_0008_5472_CAN_20_1723
crossref_primary_10_3892_ijmm_2014_1847
crossref_primary_10_1016_j_tips_2015_05_006
crossref_primary_10_1073_pnas_1419690112
crossref_primary_10_1016_j_tem_2013_12_004
crossref_primary_10_1016_j_clml_2020_12_007
crossref_primary_10_1038_s41598_019_49470_w
crossref_primary_10_1016_j_celrep_2015_06_054
crossref_primary_10_1017_erm_2015_3
crossref_primary_10_1016_j_gene_2022_146902
crossref_primary_10_1016_j_cell_2015_12_025
crossref_primary_10_1186_s12964_018_0220_7
crossref_primary_10_1146_annurev_med_051215_031109
crossref_primary_10_1080_08977194_2019_1626380
crossref_primary_10_1007_s11523_019_00648_2
crossref_primary_10_1097_IOP_0000000000000388
crossref_primary_10_1038_nsmb_3481
crossref_primary_10_1016_j_jgg_2022_12_006
crossref_primary_10_1101_gad_211649_112
crossref_primary_10_1186_s12964_017_0163_4
crossref_primary_10_1242_dev_120154
crossref_primary_10_1038_s41467_022_31722_5
crossref_primary_10_3762_bjoc_9_267
crossref_primary_10_4093_dmj_2018_42_2_117
crossref_primary_10_1016_j_semcancer_2019_04_003
crossref_primary_10_1155_2018_6134186
crossref_primary_10_1016_j_bone_2017_08_008
crossref_primary_10_1016_j_jnutbio_2017_01_007
crossref_primary_10_1007_s40257_024_00870_3
crossref_primary_10_7554_eLife_61804
crossref_primary_10_1083_jcb_202004179
crossref_primary_10_18632_aging_103334
crossref_primary_10_1016_j_tcb_2013_05_004
crossref_primary_10_1038_onc_2013_343
crossref_primary_10_1126_scisignal_aad0353
crossref_primary_10_1021_acs_jmedchem_9b00188
crossref_primary_10_3892_ol_2018_8142
crossref_primary_10_1038_nchembio_1776
crossref_primary_10_1053_j_gastro_2017_12_022
crossref_primary_10_1016_j_stem_2017_08_018
crossref_primary_10_3109_13813455_2013_796995
crossref_primary_10_1038_cddis_2016_195
Cites_doi 10.1038/nn2059
10.1101/gad.17420111
10.1101/gad.1025302
10.2337/db10-1628
10.1200/JCO.2010.27.9943
10.1242/jcs.079699
10.1172/JCI57132
10.1038/nm.2011
10.1038/nature11066
10.1038/nature07813
10.1038/nature07459
10.1084/jem.20110278
10.1034/j.1600-0463.2001.d01-140.x
10.1042/BJ20061723
10.1016/j.cell.2008.08.021
10.2147/OTT.S21957
10.1016/j.devcel.2005.12.014
10.1038/nchembio753
10.1096/fj.10-159723
10.1517/14728222.2011.617367
10.2337/diabetes.51.4.921
10.1016/j.cmet.2011.03.006
10.1038/nrg2984
10.1073/pnas.0812110106
10.1073/pnas.1018217108
10.1038/nchembio.765
10.1158/0008-5472.CAN-09-0756
10.1172/JCI25764
10.1126/science.1139740
10.1038/nature04117
10.1016/S0925-4439(01)00071-0
10.1056/NEJMra022219
10.1073/pnas.182542899
10.1056/NEJMoa1113538
10.1161/01.RES.0000256090.42690.05
10.1038/ncb2117
10.1126/scisignal.2000431
10.1056/NEJMoa1113713
10.1073/pnas.0813373106
10.1038/287795a0
10.1038/ncb435
10.1073/pnas.0602852103
10.1056/NEJMoa0905360
10.1073/pnas.0910712107
10.1016/j.neuron.2009.03.022
10.1016/j.molmed.2011.04.001
10.1007/978-1-59745-516-9_6
10.4161/cc.9.3.10591
10.1074/jbc.M110.197111
10.1124/mol.110.069708
10.1016/j.cell.2009.12.027
10.1073/pnas.1017945108
10.3109/00365517509095787
10.1016/j.tips.2010.02.002
10.1016/j.cmet.2005.11.012
10.1038/nature07275
10.1146/annurev-cellbio-092910-154048
10.1016/j.tcb.2007.06.007
10.1038/nrc3079
10.1073/pnas.0600880103
10.1126/science.1160809
ContentType Journal Article
Copyright 2012 Elsevier Inc.
Copyright © 2012 Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2012 Elsevier Inc.
– notice: Copyright © 2012 Elsevier Inc. All rights reserved.
DBID 6I.
AAFTH
FBQ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1016/j.cell.2012.09.021
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
AGRIS
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE


Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: FBQ
  name: AGRIS
  url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1097-4172
EndPage 426
ExternalDocumentID 10_1016_j_cell_2012_09_021
23063129
US201600006566
S0092867412011282
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Austrian Science Fund FWF
  grantid: P 23729
– fundername: Austrian Science Fund FWF
  grantid: I 1207
GroupedDBID ---
--K
-DZ
-ET
-~X
0R~
0WA
1RT
1~5
29B
2FS
2WC
3EH
4.4
457
4G.
53G
5GY
5RE
5VS
62-
6I.
6J9
7-5
85S
9M8
AACTN
AAEDT
AAEDW
AAFTH
AAFWJ
AAIAV
AAIKJ
AAKRW
AAKUH
AAQFI
AAUCE
AAVLU
AAXJY
AAXUO
AAYJJ
ABCQX
ABJNI
ABMAC
ABMWF
ABOCM
ABTAH
ABVKL
ACGFO
ACGFS
ACNCT
ADBBV
ADEZE
ADJPV
AEFWE
AENEX
AEXQZ
AFDAS
AFTJW
AGHFR
AGHSJ
AGKMS
AHHHB
AIDAL
AITUG
ALKID
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ASPBG
AVWKF
AZFZN
BAWUL
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
FCP
FDB
FIRID
HH5
HZ~
IH2
IHE
IXB
J1W
JIG
K-O
KOO
KQ8
L7B
LX5
M3Z
M41
N9A
NCXOZ
O-L
O9-
OK1
P2P
RCE
RIG
RNS
ROL
RPZ
SCP
SDG
SDP
SES
SSZ
TAE
TN5
TR2
TWZ
UKR
UPT
VQA
WH7
WQ6
YYQ
YZZ
ZA5
ZCA
ZY4
.-4
.55
.GJ
.HR
1CY
1VV
2KS
3O-
6TJ
AALRI
AAQXK
ABEFU
ABPTK
ADMUD
AEQTP
AETEA
AI.
FBQ
FEDTE
FGOYB
G-2
G8K
HVGLF
H~9
MVM
OHT
OMK
OZT
PUQ
R2-
UBW
UHB
VH1
X7M
XFK
YYP
ZGI
ZHY
ZKB
0SF
AAHBH
AAMRU
ADVLN
AKAPO
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
ABDPE
ACRPL
ADNMO
CITATION
7X8
ID FETCH-LOGICAL-c424t-a48a38f1c18b78cc14bc5979afe68fb397bd026d1b141aeea20951bec94907be3
IEDL.DBID ABVKL
ISSN 0092-8674
IngestDate Sat Oct 05 04:57:05 EDT 2024
Fri Dec 06 02:39:15 EST 2024
Sat Sep 28 08:26:44 EDT 2024
Wed Dec 27 19:10:26 EST 2023
Fri Feb 23 02:30:35 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License http://www.elsevier.com/open-access/userlicense/1.0
Copyright © 2012 Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c424t-a48a38f1c18b78cc14bc5979afe68fb397bd026d1b141aeea20951bec94907be3
Notes http://dx.doi.org/10.1016/j.cell.2012.09.021
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.sciencedirect.com/science/article/pii/S0092867412011282
PMID 23063129
PQID 1112342715
PQPubID 23479
PageCount 13
ParticipantIDs proquest_miscellaneous_1112342715
crossref_primary_10_1016_j_cell_2012_09_021
pubmed_primary_23063129
fao_agris_US201600006566
elsevier_sciencedirect_doi_10_1016_j_cell_2012_09_021
PublicationCentury 2000
PublicationDate 2012-10-12
PublicationDateYYYYMMDD 2012-10-12
PublicationDate_xml – month: 10
  year: 2012
  text: 2012-10-12
  day: 12
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Cell
PublicationTitleAlternate Cell
PublicationYear 2012
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Cantó, Auwerx (bib4) 2011; 26
Varjosalo, Li, Taipale (bib50) 2006; 10
Pospisilik, Schramek, Schnidar, Cronin, Nehme, Zhang, Knauf, Cani, Aumayr, Todoric (bib30) 2010; 140
Theunissen, de Sauvage (bib45) 2009; 69
Corcoran, Scott (bib10) 2006; 103
Yauch, Gould, Scales, Tang, Tian, Ahn, Marshall, Fu, Januario, Kallop (bib57) 2008; 455
Li, Maitah, Ahmad, Kong, Bao, Sarkar (bib19) 2012; 16
Han, Spassky, Romaguera-Ros, Garcia-Verdugo, Aguilar, Schneider-Maunoury, Alvarez-Buylla (bib12) 2008; 11
Hsu, Sabatini (bib15) 2008; 134
Ng, Curran (bib26) 2011; 11
Rohatgi, Milenkovic, Scott (bib35) 2007; 317
Towler, Hardie (bib47) 2007; 100
Yam, Langlois, Morin, Charron (bib56) 2009; 62
Hitosugi, Kang, Vander Heiden, Chung, Elf, Lythgoe, Dong, Lonial, Wang, Chen (bib14) 2009; 2
Chen, Taipale, Cooper, Beachy (bib5) 2002; 16
Ogden, Fei, Schilling, Ahmed, Hwa, Robbins (bib28) 2008; 456
Hardie (bib13) 2011; 25
Rohatgi, Scott (bib34) 2007; 9
Wang, Lu, Bond, Chen, Ren, Lyerly, Barak, Chen (bib53) 2010; 107
Wong, Seol, So, Ermilov, Bichakjian, Epstein, Dlugosz, Reiter (bib55) 2009; 15
Riggs, Hartmann (bib31) 2003; 348
Polizio, Chinchilla, Chen, Kim, Manning, Riobo (bib29) 2011; 286
Chen, Tang, Eastham-Anderson, Dunlap, Alicke, Nannini, Gould, Yauch, Modrusan, DuPree (bib7) 2011; 108
Tsou, Zheng, Hsu, Sasaki, Cantley (bib48) 2011; 13
Hui, Angers (bib16) 2011; 27
Nachtergaele, Mydock, Krishnan, Rammohan, Schlesinger, Covey, Rohatgi (bib25) 2012; 8
Todoric, Strobl, Jais, Boucheron, Bayer, Amann, Lindroos, Teperino, Prager, Bilban (bib46) 2011; 60
Lin, Matsui (bib20) 2012; 5
Vander Heiden, Cantley, Thompson (bib49) 2009; 324
Chen, Taipale, Young, Maiti, Beachy (bib6) 2002; 99
Von Hoff, LoRusso, Rudin, Reddy, Yauch, Tibes, Weiss, Borad, Hann, Brahmer (bib51) 2009; 361
Sinha, Chen (bib41) 2006; 2
Wang, Zhou, Walsh, McMahon (bib52) 2009; 106
Shi, Wang, Huang, Vogel, Neale, Green, Chi (bib40) 2011; 208
Ruiz i Altaba, Mas, Stecca (bib38) 2007; 17
Belgacem, Borodinsky (bib1) 2011; 108
Boehlke, Kotsis, Patel, Braeg, Voelker, Bredt, Beyer, Janusch, Hamann, Gödel (bib2) 2010; 12
Gaster, Petersen, Højlund, Poulsen, Beck-Nielsen (bib11) 2002; 51
Suh, Gao, McKay, McKay, Salo, Graff (bib42) 2006; 3
Chinchilla, Xiao, Kazanietz, Riobo (bib8) 2010; 9
Corbit, Aanstad, Singla, Norman, Stainier, Reiter (bib9) 2005; 437
Roudaut, Traiffort, Gorojankina, Vincent, Faure, Schoenfelder, Mann, Manetti, Solinas, Taddei, Ruat (bib37) 2011; 79
Lumeng, Saltiel (bib24) 2011; 121
Nüsslein-Volhard, Wieschaus (bib27) 1980; 287
Jeon, Chandel, Hay (bib18) 2012; 485
Riobo, Manning (bib32) 2007; 403
Ingham, Nakano, Seger (bib17) 2011; 12
Calebiro, Nikolaev, Persani, Lohse (bib3) 2010; 31
Whittle, López, Vidal-Puig (bib54) 2011; 17
Lowe, O’Rahilly, Rochford (bib23) 2011; 124
Riobo, Saucy, Dilizio, Manning (bib33) 2006; 103
Rohatgi, Milenkovic, Corcoran, Scott (bib36) 2009; 106
Tang, Mackay-Wiggan, Aszterbaum, Yauch, Lindgren, Chang, Coppola, Chanana, Marji, Bickers, Epstein (bib43) 2012; 366
Teglund, Toftgård (bib44) 2010; 1805
Low, de Sauvage (bib22) 2010; 28
Sekulic, Migden, Oro, Dirix, Lewis, Hainsworth, Solomon, Yoo, Arron, Friedlander (bib39) 2012; 366
Liu, Gauthier, Sun, Ruderman, Lodish (bib21) 2010; 24
23063118 - Cell. 2012 Oct 12;151(2):248-50
Belgacem (10.1016/j.cell.2012.09.021_bib1) 2011; 108
Chinchilla (10.1016/j.cell.2012.09.021_bib8) 2010; 9
Pospisilik (10.1016/j.cell.2012.09.021_bib30) 2010; 140
Jeon (10.1016/j.cell.2012.09.021_bib18) 2012; 485
Riobo (10.1016/j.cell.2012.09.021_bib33) 2006; 103
Liu (10.1016/j.cell.2012.09.021_bib21) 2010; 24
Chen (10.1016/j.cell.2012.09.021_bib7) 2011; 108
Rohatgi (10.1016/j.cell.2012.09.021_bib36) 2009; 106
Boehlke (10.1016/j.cell.2012.09.021_bib2) 2010; 12
Hsu (10.1016/j.cell.2012.09.021_bib15) 2008; 134
Lumeng (10.1016/j.cell.2012.09.021_bib24) 2011; 121
Sinha (10.1016/j.cell.2012.09.021_bib41) 2006; 2
Tsou (10.1016/j.cell.2012.09.021_bib48) 2011; 13
Corcoran (10.1016/j.cell.2012.09.021_bib10) 2006; 103
Suh (10.1016/j.cell.2012.09.021_bib42) 2006; 3
Chen (10.1016/j.cell.2012.09.021_bib5) 2002; 16
Whittle (10.1016/j.cell.2012.09.021_bib54) 2011; 17
Wang (10.1016/j.cell.2012.09.021_bib53) 2010; 107
Theunissen (10.1016/j.cell.2012.09.021_bib45) 2009; 69
Varjosalo (10.1016/j.cell.2012.09.021_bib50) 2006; 10
Nachtergaele (10.1016/j.cell.2012.09.021_bib25) 2012; 8
Teglund (10.1016/j.cell.2012.09.021_bib44) 2010; 1805
Yauch (10.1016/j.cell.2012.09.021_bib57) 2008; 455
Riobo (10.1016/j.cell.2012.09.021_bib32) 2007; 403
10.1016/j.cell.2012.09.021_bib63
Hardie (10.1016/j.cell.2012.09.021_bib13) 2011; 25
Von Hoff (10.1016/j.cell.2012.09.021_bib51) 2009; 361
10.1016/j.cell.2012.09.021_bib62
10.1016/j.cell.2012.09.021_bib61
10.1016/j.cell.2012.09.021_bib60
Corbit (10.1016/j.cell.2012.09.021_bib9) 2005; 437
Wong (10.1016/j.cell.2012.09.021_bib55) 2009; 15
Ingham (10.1016/j.cell.2012.09.021_bib17) 2011; 12
Nüsslein-Volhard (10.1016/j.cell.2012.09.021_bib27) 1980; 287
Yam (10.1016/j.cell.2012.09.021_bib56) 2009; 62
Han (10.1016/j.cell.2012.09.021_bib12) 2008; 11
Sekulic (10.1016/j.cell.2012.09.021_bib39) 2012; 366
Chen (10.1016/j.cell.2012.09.021_bib6) 2002; 99
Lowe (10.1016/j.cell.2012.09.021_bib23) 2011; 124
Hitosugi (10.1016/j.cell.2012.09.021_bib14) 2009; 2
Riggs (10.1016/j.cell.2012.09.021_bib31) 2003; 348
10.1016/j.cell.2012.09.021_bib59
10.1016/j.cell.2012.09.021_bib58
Lin (10.1016/j.cell.2012.09.021_bib20) 2012; 5
Hui (10.1016/j.cell.2012.09.021_bib16) 2011; 27
Ruiz i Altaba (10.1016/j.cell.2012.09.021_bib38) 2007; 17
Vander Heiden (10.1016/j.cell.2012.09.021_bib49) 2009; 324
Ogden (10.1016/j.cell.2012.09.021_bib28) 2008; 456
Roudaut (10.1016/j.cell.2012.09.021_bib37) 2011; 79
Cantó (10.1016/j.cell.2012.09.021_bib4) 2011; 26
Ng (10.1016/j.cell.2012.09.021_bib26) 2011; 11
Wang (10.1016/j.cell.2012.09.021_bib52) 2009; 106
Rohatgi (10.1016/j.cell.2012.09.021_bib34) 2007; 9
Tang (10.1016/j.cell.2012.09.021_bib43) 2012; 366
Towler (10.1016/j.cell.2012.09.021_bib47) 2007; 100
Calebiro (10.1016/j.cell.2012.09.021_bib3) 2010; 31
Li (10.1016/j.cell.2012.09.021_bib19) 2012; 16
Todoric (10.1016/j.cell.2012.09.021_bib46) 2011; 60
Rohatgi (10.1016/j.cell.2012.09.021_bib35) 2007; 317
Low (10.1016/j.cell.2012.09.021_bib22) 2010; 28
Polizio (10.1016/j.cell.2012.09.021_bib29) 2011; 286
Gaster (10.1016/j.cell.2012.09.021_bib11) 2002; 51
Shi (10.1016/j.cell.2012.09.021_bib40) 2011; 208
References_xml – volume: 2
  start-page: ra73
  year: 2009
  ident: bib14
  article-title: Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
  publication-title: Sci. Signal.
  contributor:
    fullname: Chen
– volume: 107
  start-page: 9323
  year: 2010
  end-page: 9328
  ident: bib53
  article-title: Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Chen
– volume: 9
  start-page: 1005
  year: 2007
  end-page: 1009
  ident: bib34
  article-title: Patching the gaps in Hedgehog signalling
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Scott
– volume: 26
  start-page: 214
  year: 2011
  end-page: 224
  ident: bib4
  article-title: Calorie restriction: is AMPK a key sensor and effector?
  publication-title: Physiology (Bethesda)
  contributor:
    fullname: Auwerx
– volume: 12
  start-page: 1115
  year: 2010
  end-page: 1122
  ident: bib2
  article-title: Primary cilia regulate mTORC1 activity and cell size through Lkb1
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Gödel
– volume: 16
  start-page: 49
  year: 2012
  end-page: 66
  ident: bib19
  article-title: Targeting the Hedgehog signaling pathway for cancer therapy
  publication-title: Expert Opin. Ther. Targets
  contributor:
    fullname: Sarkar
– volume: 103
  start-page: 8408
  year: 2006
  end-page: 8413
  ident: bib10
  article-title: Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Scott
– volume: 16
  start-page: 2743
  year: 2002
  end-page: 2748
  ident: bib5
  article-title: Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
  publication-title: Genes Dev.
  contributor:
    fullname: Beachy
– volume: 28
  start-page: 5321
  year: 2010
  end-page: 5326
  ident: bib22
  article-title: Clinical experience with Hedgehog pathway inhibitors
  publication-title: J. Clin. Oncol.
  contributor:
    fullname: de Sauvage
– volume: 5
  start-page: 47
  year: 2012
  end-page: 58
  ident: bib20
  article-title: Hedgehog pathway as a drug target: Smoothened inhibitors in development
  publication-title: Onco. Targets Ther.
  contributor:
    fullname: Matsui
– volume: 24
  start-page: 4229
  year: 2010
  end-page: 4239
  ident: bib21
  article-title: Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio
  publication-title: FASEB J.
  contributor:
    fullname: Lodish
– volume: 103
  start-page: 12607
  year: 2006
  end-page: 12612
  ident: bib33
  article-title: Activation of heterotrimeric G proteins by Smoothened
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Manning
– volume: 31
  start-page: 221
  year: 2010
  end-page: 228
  ident: bib3
  article-title: Signaling by internalized G-protein-coupled receptors
  publication-title: Trends Pharmacol. Sci.
  contributor:
    fullname: Lohse
– volume: 348
  start-page: 618
  year: 2003
  end-page: 629
  ident: bib31
  article-title: Selective estrogen-receptor modulators — mechanisms of action and application to clinical practice
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Hartmann
– volume: 12
  start-page: 393
  year: 2011
  end-page: 406
  ident: bib17
  article-title: Mechanisms and functions of Hedgehog signalling across the metazoa
  publication-title: Nat. Rev. Genet.
  contributor:
    fullname: Seger
– volume: 437
  start-page: 1018
  year: 2005
  end-page: 1021
  ident: bib9
  article-title: Vertebrate Smoothened functions at the primary cilium
  publication-title: Nature
  contributor:
    fullname: Reiter
– volume: 286
  start-page: 19589
  year: 2011
  end-page: 19596
  ident: bib29
  article-title: Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Riobo
– volume: 17
  start-page: 438
  year: 2007
  end-page: 447
  ident: bib38
  article-title: The Gli code: an information nexus regulating cell fate, stemness and cancer
  publication-title: Trends Cell Biol.
  contributor:
    fullname: Stecca
– volume: 9
  start-page: 570
  year: 2010
  end-page: 579
  ident: bib8
  article-title: Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
  publication-title: Cell Cycle
  contributor:
    fullname: Riobo
– volume: 456
  start-page: 967
  year: 2008
  end-page: 970
  ident: bib28
  article-title: G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
  publication-title: Nature
  contributor:
    fullname: Robbins
– volume: 2
  start-page: 29
  year: 2006
  end-page: 30
  ident: bib41
  article-title: Purmorphamine activates the Hedgehog pathway by targeting Smoothened
  publication-title: Nat. Chem. Biol.
  contributor:
    fullname: Chen
– volume: 485
  start-page: 661
  year: 2012
  end-page: 665
  ident: bib18
  article-title: AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
  publication-title: Nature
  contributor:
    fullname: Hay
– volume: 140
  start-page: 148
  year: 2010
  end-page: 160
  ident: bib30
  article-title: Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
  publication-title: Cell
  contributor:
    fullname: Todoric
– volume: 27
  start-page: 513
  year: 2011
  end-page: 537
  ident: bib16
  article-title: Gli proteins in development and disease
  publication-title: Annu. Rev. Cell Dev. Biol.
  contributor:
    fullname: Angers
– volume: 361
  start-page: 1164
  year: 2009
  end-page: 1172
  ident: bib51
  article-title: Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Brahmer
– volume: 11
  start-page: 277
  year: 2008
  end-page: 284
  ident: bib12
  article-title: Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
  publication-title: Nat. Neurosci.
  contributor:
    fullname: Alvarez-Buylla
– volume: 17
  start-page: 405
  year: 2011
  end-page: 411
  ident: bib54
  article-title: Using brown adipose tissue to treat obesity - the central issue
  publication-title: Trends Mol. Med.
  contributor:
    fullname: Vidal-Puig
– volume: 108
  start-page: 4482
  year: 2011
  end-page: 4487
  ident: bib1
  article-title: Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Borodinsky
– volume: 11
  start-page: 493
  year: 2011
  end-page: 501
  ident: bib26
  article-title: The Hedgehog’s tale: developing strategies for targeting cancer
  publication-title: Nat. Rev. Cancer
  contributor:
    fullname: Curran
– volume: 121
  start-page: 2111
  year: 2011
  end-page: 2117
  ident: bib24
  article-title: Inflammatory links between obesity and metabolic disease
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Saltiel
– volume: 3
  start-page: 25
  year: 2006
  end-page: 34
  ident: bib42
  article-title: Hedgehog signaling plays a conserved role in inhibiting fat formation
  publication-title: Cell Metab.
  contributor:
    fullname: Graff
– volume: 79
  start-page: 453
  year: 2011
  end-page: 460
  ident: bib37
  article-title: Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Ruat
– volume: 62
  start-page: 349
  year: 2009
  end-page: 362
  ident: bib56
  article-title: Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
  publication-title: Neuron
  contributor:
    fullname: Charron
– volume: 60
  start-page: 1668
  year: 2011
  end-page: 1676
  ident: bib46
  article-title: Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis
  publication-title: Diabetes
  contributor:
    fullname: Bilban
– volume: 287
  start-page: 795
  year: 1980
  end-page: 801
  ident: bib27
  article-title: Mutations affecting segment number and polarity in Drosophila
  publication-title: Nature
  contributor:
    fullname: Wieschaus
– volume: 25
  start-page: 1895
  year: 2011
  end-page: 1908
  ident: bib13
  article-title: AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
  publication-title: Genes Dev.
  contributor:
    fullname: Hardie
– volume: 51
  start-page: 921
  year: 2002
  end-page: 927
  ident: bib11
  article-title: The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity
  publication-title: Diabetes
  contributor:
    fullname: Beck-Nielsen
– volume: 8
  start-page: 211
  year: 2012
  end-page: 220
  ident: bib25
  article-title: Oxysterols are allosteric activators of the oncoprotein Smoothened
  publication-title: Nat. Chem. Biol.
  contributor:
    fullname: Rohatgi
– volume: 317
  start-page: 372
  year: 2007
  end-page: 376
  ident: bib35
  article-title: Patched1 regulates hedgehog signaling at the primary cilium
  publication-title: Science
  contributor:
    fullname: Scott
– volume: 403
  start-page: 369
  year: 2007
  end-page: 379
  ident: bib32
  article-title: Pathways of signal transduction employed by vertebrate Hedgehogs
  publication-title: Biochem. J.
  contributor:
    fullname: Manning
– volume: 106
  start-page: 3196
  year: 2009
  end-page: 3201
  ident: bib36
  article-title: Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Scott
– volume: 366
  start-page: 2180
  year: 2012
  end-page: 2188
  ident: bib43
  article-title: Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Epstein
– volume: 455
  start-page: 406
  year: 2008
  end-page: 410
  ident: bib57
  article-title: A paracrine requirement for hedgehog signalling in cancer
  publication-title: Nature
  contributor:
    fullname: Kallop
– volume: 10
  start-page: 177
  year: 2006
  end-page: 186
  ident: bib50
  article-title: Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
  publication-title: Dev. Cell
  contributor:
    fullname: Taipale
– volume: 366
  start-page: 2171
  year: 2012
  end-page: 2179
  ident: bib39
  article-title: Efficacy and safety of vismodegib in advanced basal-cell carcinoma
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Friedlander
– volume: 99
  start-page: 14071
  year: 2002
  end-page: 14076
  ident: bib6
  article-title: Small molecule modulation of Smoothened activity
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Beachy
– volume: 124
  start-page: 2681
  year: 2011
  end-page: 2686
  ident: bib23
  article-title: Adipogenesis at a glance
  publication-title: J. Cell Sci.
  contributor:
    fullname: Rochford
– volume: 208
  start-page: 1367
  year: 2011
  end-page: 1376
  ident: bib40
  article-title: HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
  publication-title: J. Exp. Med.
  contributor:
    fullname: Chi
– volume: 106
  start-page: 2623
  year: 2009
  end-page: 2628
  ident: bib52
  article-title: Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: McMahon
– volume: 324
  start-page: 1029
  year: 2009
  end-page: 1033
  ident: bib49
  article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation
  publication-title: Science
  contributor:
    fullname: Thompson
– volume: 100
  start-page: 328
  year: 2007
  end-page: 341
  ident: bib47
  article-title: AMP-activated protein kinase in metabolic control and insulin signaling
  publication-title: Circ. Res.
  contributor:
    fullname: Hardie
– volume: 1805
  start-page: 181
  year: 2010
  end-page: 208
  ident: bib44
  article-title: Hedgehog beyond medulloblastoma and basal cell carcinoma
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Toftgård
– volume: 108
  start-page: 9589
  year: 2011
  end-page: 9594
  ident: bib7
  article-title: Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: DuPree
– volume: 134
  start-page: 703
  year: 2008
  end-page: 707
  ident: bib15
  article-title: Cancer cell metabolism: Warburg and beyond
  publication-title: Cell
  contributor:
    fullname: Sabatini
– volume: 13
  start-page: 476
  year: 2011
  end-page: 486
  ident: bib48
  article-title: A fluorescent reporter of AMPK activity and cellular energy stress
  publication-title: Cell Metab.
  contributor:
    fullname: Cantley
– volume: 15
  start-page: 1055
  year: 2009
  end-page: 1061
  ident: bib55
  article-title: Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis
  publication-title: Nat. Med.
  contributor:
    fullname: Reiter
– volume: 69
  start-page: 6007
  year: 2009
  end-page: 6010
  ident: bib45
  article-title: Paracrine Hedgehog signaling in cancer
  publication-title: Cancer Res.
  contributor:
    fullname: de Sauvage
– volume: 11
  start-page: 277
  year: 2008
  ident: 10.1016/j.cell.2012.09.021_bib12
  article-title: Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn2059
  contributor:
    fullname: Han
– volume: 25
  start-page: 1895
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib13
  article-title: AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
  publication-title: Genes Dev.
  doi: 10.1101/gad.17420111
  contributor:
    fullname: Hardie
– volume: 16
  start-page: 2743
  year: 2002
  ident: 10.1016/j.cell.2012.09.021_bib5
  article-title: Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
  publication-title: Genes Dev.
  doi: 10.1101/gad.1025302
  contributor:
    fullname: Chen
– volume: 60
  start-page: 1668
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib46
  article-title: Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis
  publication-title: Diabetes
  doi: 10.2337/db10-1628
  contributor:
    fullname: Todoric
– volume: 28
  start-page: 5321
  year: 2010
  ident: 10.1016/j.cell.2012.09.021_bib22
  article-title: Clinical experience with Hedgehog pathway inhibitors
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2010.27.9943
  contributor:
    fullname: Low
– volume: 124
  start-page: 2681
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib23
  article-title: Adipogenesis at a glance
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.079699
  contributor:
    fullname: Lowe
– volume: 121
  start-page: 2111
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib24
  article-title: Inflammatory links between obesity and metabolic disease
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI57132
  contributor:
    fullname: Lumeng
– volume: 15
  start-page: 1055
  year: 2009
  ident: 10.1016/j.cell.2012.09.021_bib55
  article-title: Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis
  publication-title: Nat. Med.
  doi: 10.1038/nm.2011
  contributor:
    fullname: Wong
– volume: 26
  start-page: 214
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib4
  article-title: Calorie restriction: is AMPK a key sensor and effector?
  publication-title: Physiology (Bethesda)
  contributor:
    fullname: Cantó
– volume: 485
  start-page: 661
  year: 2012
  ident: 10.1016/j.cell.2012.09.021_bib18
  article-title: AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
  publication-title: Nature
  doi: 10.1038/nature11066
  contributor:
    fullname: Jeon
– ident: 10.1016/j.cell.2012.09.021_bib59
  doi: 10.1038/nature07813
– volume: 456
  start-page: 967
  year: 2008
  ident: 10.1016/j.cell.2012.09.021_bib28
  article-title: G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
  publication-title: Nature
  doi: 10.1038/nature07459
  contributor:
    fullname: Ogden
– volume: 208
  start-page: 1367
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib40
  article-title: HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20110278
  contributor:
    fullname: Shi
– ident: 10.1016/j.cell.2012.09.021_bib60
  doi: 10.1034/j.1600-0463.2001.d01-140.x
– volume: 403
  start-page: 369
  year: 2007
  ident: 10.1016/j.cell.2012.09.021_bib32
  article-title: Pathways of signal transduction employed by vertebrate Hedgehogs
  publication-title: Biochem. J.
  doi: 10.1042/BJ20061723
  contributor:
    fullname: Riobo
– volume: 134
  start-page: 703
  year: 2008
  ident: 10.1016/j.cell.2012.09.021_bib15
  article-title: Cancer cell metabolism: Warburg and beyond
  publication-title: Cell
  doi: 10.1016/j.cell.2008.08.021
  contributor:
    fullname: Hsu
– volume: 5
  start-page: 47
  year: 2012
  ident: 10.1016/j.cell.2012.09.021_bib20
  article-title: Hedgehog pathway as a drug target: Smoothened inhibitors in development
  publication-title: Onco. Targets Ther.
  doi: 10.2147/OTT.S21957
  contributor:
    fullname: Lin
– volume: 10
  start-page: 177
  year: 2006
  ident: 10.1016/j.cell.2012.09.021_bib50
  article-title: Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2005.12.014
  contributor:
    fullname: Varjosalo
– volume: 2
  start-page: 29
  year: 2006
  ident: 10.1016/j.cell.2012.09.021_bib41
  article-title: Purmorphamine activates the Hedgehog pathway by targeting Smoothened
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio753
  contributor:
    fullname: Sinha
– volume: 24
  start-page: 4229
  year: 2010
  ident: 10.1016/j.cell.2012.09.021_bib21
  article-title: Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio
  publication-title: FASEB J.
  doi: 10.1096/fj.10-159723
  contributor:
    fullname: Liu
– volume: 16
  start-page: 49
  year: 2012
  ident: 10.1016/j.cell.2012.09.021_bib19
  article-title: Targeting the Hedgehog signaling pathway for cancer therapy
  publication-title: Expert Opin. Ther. Targets
  doi: 10.1517/14728222.2011.617367
  contributor:
    fullname: Li
– volume: 51
  start-page: 921
  year: 2002
  ident: 10.1016/j.cell.2012.09.021_bib11
  article-title: The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.4.921
  contributor:
    fullname: Gaster
– volume: 13
  start-page: 476
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib48
  article-title: A fluorescent reporter of AMPK activity and cellular energy stress
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2011.03.006
  contributor:
    fullname: Tsou
– volume: 12
  start-page: 393
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib17
  article-title: Mechanisms and functions of Hedgehog signalling across the metazoa
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2984
  contributor:
    fullname: Ingham
– volume: 106
  start-page: 2623
  year: 2009
  ident: 10.1016/j.cell.2012.09.021_bib52
  article-title: Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0812110106
  contributor:
    fullname: Wang
– volume: 108
  start-page: 4482
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib1
  article-title: Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1018217108
  contributor:
    fullname: Belgacem
– volume: 8
  start-page: 211
  year: 2012
  ident: 10.1016/j.cell.2012.09.021_bib25
  article-title: Oxysterols are allosteric activators of the oncoprotein Smoothened
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.765
  contributor:
    fullname: Nachtergaele
– volume: 69
  start-page: 6007
  year: 2009
  ident: 10.1016/j.cell.2012.09.021_bib45
  article-title: Paracrine Hedgehog signaling in cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-0756
  contributor:
    fullname: Theunissen
– ident: 10.1016/j.cell.2012.09.021_bib63
  doi: 10.1172/JCI25764
– volume: 317
  start-page: 372
  year: 2007
  ident: 10.1016/j.cell.2012.09.021_bib35
  article-title: Patched1 regulates hedgehog signaling at the primary cilium
  publication-title: Science
  doi: 10.1126/science.1139740
  contributor:
    fullname: Rohatgi
– volume: 437
  start-page: 1018
  year: 2005
  ident: 10.1016/j.cell.2012.09.021_bib9
  article-title: Vertebrate Smoothened functions at the primary cilium
  publication-title: Nature
  doi: 10.1038/nature04117
  contributor:
    fullname: Corbit
– ident: 10.1016/j.cell.2012.09.021_bib61
  doi: 10.1016/S0925-4439(01)00071-0
– volume: 348
  start-page: 618
  year: 2003
  ident: 10.1016/j.cell.2012.09.021_bib31
  article-title: Selective estrogen-receptor modulators — mechanisms of action and application to clinical practice
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra022219
  contributor:
    fullname: Riggs
– volume: 99
  start-page: 14071
  year: 2002
  ident: 10.1016/j.cell.2012.09.021_bib6
  article-title: Small molecule modulation of Smoothened activity
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.182542899
  contributor:
    fullname: Chen
– volume: 366
  start-page: 2180
  year: 2012
  ident: 10.1016/j.cell.2012.09.021_bib43
  article-title: Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1113538
  contributor:
    fullname: Tang
– volume: 1805
  start-page: 181
  year: 2010
  ident: 10.1016/j.cell.2012.09.021_bib44
  article-title: Hedgehog beyond medulloblastoma and basal cell carcinoma
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Teglund
– volume: 100
  start-page: 328
  year: 2007
  ident: 10.1016/j.cell.2012.09.021_bib47
  article-title: AMP-activated protein kinase in metabolic control and insulin signaling
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000256090.42690.05
  contributor:
    fullname: Towler
– volume: 12
  start-page: 1115
  year: 2010
  ident: 10.1016/j.cell.2012.09.021_bib2
  article-title: Primary cilia regulate mTORC1 activity and cell size through Lkb1
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2117
  contributor:
    fullname: Boehlke
– volume: 2
  start-page: ra73
  year: 2009
  ident: 10.1016/j.cell.2012.09.021_bib14
  article-title: Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2000431
  contributor:
    fullname: Hitosugi
– volume: 366
  start-page: 2171
  year: 2012
  ident: 10.1016/j.cell.2012.09.021_bib39
  article-title: Efficacy and safety of vismodegib in advanced basal-cell carcinoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1113713
  contributor:
    fullname: Sekulic
– volume: 106
  start-page: 3196
  year: 2009
  ident: 10.1016/j.cell.2012.09.021_bib36
  article-title: Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0813373106
  contributor:
    fullname: Rohatgi
– volume: 287
  start-page: 795
  year: 1980
  ident: 10.1016/j.cell.2012.09.021_bib27
  article-title: Mutations affecting segment number and polarity in Drosophila
  publication-title: Nature
  doi: 10.1038/287795a0
  contributor:
    fullname: Nüsslein-Volhard
– volume: 9
  start-page: 1005
  year: 2007
  ident: 10.1016/j.cell.2012.09.021_bib34
  article-title: Patching the gaps in Hedgehog signalling
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb435
  contributor:
    fullname: Rohatgi
– volume: 103
  start-page: 8408
  year: 2006
  ident: 10.1016/j.cell.2012.09.021_bib10
  article-title: Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0602852103
  contributor:
    fullname: Corcoran
– volume: 361
  start-page: 1164
  year: 2009
  ident: 10.1016/j.cell.2012.09.021_bib51
  article-title: Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0905360
  contributor:
    fullname: Von Hoff
– volume: 107
  start-page: 9323
  year: 2010
  ident: 10.1016/j.cell.2012.09.021_bib53
  article-title: Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0910712107
  contributor:
    fullname: Wang
– volume: 62
  start-page: 349
  year: 2009
  ident: 10.1016/j.cell.2012.09.021_bib56
  article-title: Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
  publication-title: Neuron
  doi: 10.1016/j.neuron.2009.03.022
  contributor:
    fullname: Yam
– volume: 17
  start-page: 405
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib54
  article-title: Using brown adipose tissue to treat obesity - the central issue
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2011.04.001
  contributor:
    fullname: Whittle
– ident: 10.1016/j.cell.2012.09.021_bib62
  doi: 10.1007/978-1-59745-516-9_6
– volume: 9
  start-page: 570
  year: 2010
  ident: 10.1016/j.cell.2012.09.021_bib8
  article-title: Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.3.10591
  contributor:
    fullname: Chinchilla
– volume: 286
  start-page: 19589
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib29
  article-title: Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.197111
  contributor:
    fullname: Polizio
– volume: 79
  start-page: 453
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib37
  article-title: Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.110.069708
  contributor:
    fullname: Roudaut
– volume: 140
  start-page: 148
  year: 2010
  ident: 10.1016/j.cell.2012.09.021_bib30
  article-title: Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
  publication-title: Cell
  doi: 10.1016/j.cell.2009.12.027
  contributor:
    fullname: Pospisilik
– volume: 108
  start-page: 9589
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib7
  article-title: Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1017945108
  contributor:
    fullname: Chen
– ident: 10.1016/j.cell.2012.09.021_bib58
  doi: 10.3109/00365517509095787
– volume: 31
  start-page: 221
  year: 2010
  ident: 10.1016/j.cell.2012.09.021_bib3
  article-title: Signaling by internalized G-protein-coupled receptors
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2010.02.002
  contributor:
    fullname: Calebiro
– volume: 3
  start-page: 25
  year: 2006
  ident: 10.1016/j.cell.2012.09.021_bib42
  article-title: Hedgehog signaling plays a conserved role in inhibiting fat formation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2005.11.012
  contributor:
    fullname: Suh
– volume: 455
  start-page: 406
  year: 2008
  ident: 10.1016/j.cell.2012.09.021_bib57
  article-title: A paracrine requirement for hedgehog signalling in cancer
  publication-title: Nature
  doi: 10.1038/nature07275
  contributor:
    fullname: Yauch
– volume: 27
  start-page: 513
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib16
  article-title: Gli proteins in development and disease
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev-cellbio-092910-154048
  contributor:
    fullname: Hui
– volume: 17
  start-page: 438
  year: 2007
  ident: 10.1016/j.cell.2012.09.021_bib38
  article-title: The Gli code: an information nexus regulating cell fate, stemness and cancer
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2007.06.007
  contributor:
    fullname: Ruiz i Altaba
– volume: 11
  start-page: 493
  year: 2011
  ident: 10.1016/j.cell.2012.09.021_bib26
  article-title: The Hedgehog’s tale: developing strategies for targeting cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3079
  contributor:
    fullname: Ng
– volume: 103
  start-page: 12607
  year: 2006
  ident: 10.1016/j.cell.2012.09.021_bib33
  article-title: Activation of heterotrimeric G proteins by Smoothened
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0600880103
  contributor:
    fullname: Riobo
– volume: 324
  start-page: 1029
  year: 2009
  ident: 10.1016/j.cell.2012.09.021_bib49
  article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation
  publication-title: Science
  doi: 10.1126/science.1160809
  contributor:
    fullname: Vander Heiden
SSID ssj0008555
Score 2.5216727
Snippet Diabetes, obesity, and cancer affect upward of 15% of the world’s population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling...
Diabetes, obesity, and cancer affect upward of 15% of the world's population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling...
SourceID proquest
crossref
pubmed
fao
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 414
SubjectTerms Adipocytes - metabolism
Adipose Tissue, Brown - metabolism
agonistic behavior
agonists
Animals
brown adipose tissue
Cell Line
Cells, Cultured
Cilia - metabolism
cyclopamine
diabetes
Diabetes Mellitus - metabolism
glucose
Glycolysis
Hedgehog Proteins - metabolism
Humans
metabolism
Mice
Muscle Cells - metabolism
muscles
Neoplasms - metabolism
obesity
Obesity - metabolism
Protein Kinases - metabolism
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
signals
Smoothened Receptor
Title Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
URI https://dx.doi.org/10.1016/j.cell.2012.09.021
https://www.ncbi.nlm.nih.gov/pubmed/23063129
https://search.proquest.com/docview/1112342715
Volume 151
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB51WyFxqcqzS2llJG7Iau04iX1sl66Wx7ZIsLDiYtmOsywt2aqbPfDvmcmjEody4Ogkjuxv7JlvrJkxwOs0S4oT43JeIl3lqlCCO-0DNy7kVAva6ZTynacX2WSm3s_T-RaM-lwYCqvsdH-r0xtt3T057tA8vlkuKcfXSJ2hRSQbhp7DAHaoljku7Z3Ts68fPt4pZJ2m7UUGBjc_duhyZ9owLzofpwgv2ZQ7leI--zQo3ep-FtpYo_Ee7HY0kp22I30EW7F6DA_aiyV_P4HLCR2T_Vgt2CeaDH25wM27_sXe3lKdWfbNEZoLfr28imwaa1wK1_R6WbHpZo2_ZK4qWOOjs7Grn8JsfP5lNOHd1Qk8KKlq7pR2iS5FENrnOgShfEDXwbgyZrr0SEJ8gd5XIbxQwsXoJFEtlKdR6C37mDyD7WpVxX1gJoky8SHLisKpIISjagIyybWRZa5CPoQ3PWD2pq2QYfvQsZ-W4LUErz0xFuEdQtpjav-Ss0UV_s9--ygA6xao-uzss6TCeA1_yrIhvOqlYnFvUE9XxdVmTd6NTJTMRTqE56247oZIrleCZOfFfw7oAB5SizfBLS9hu77dxEPkJ7U_6tbfEQzezc-wdTGaX37_A-v74j4
link.rule.ids 314,780,784,3506,27569,27924,27925,45663,45874
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB4BVdVeKuiLbYG6Um-VBXacxD6Wx2ppWUAqq-7Nsh1nuy3NIjZ74N8zkwdSD_TQa_yQ84098401Mwb4lGZJcWBczkukq1wVSnCnfeDGhZxqQTudUr7z-DwbTdTXaTpdg6M-F4bCKjvd3-r0Rlt3X_Y7NPdv5nPK8TVSZ2gRyYah57AOT1Sqcyqgfzo9fFDHOk3bZwwMHn3s3mXOtEFedDtO8V2yKXYqxWPWab10i8c5aGOLhpvwoiOR7Eu7zi1Yi9VLeNo-K3n3Ci5GdEn2czFjl_Qr1HOGR3f5hx3fUpVZ9sMRljN-Pf8d2TjWuBGuqXlesfFqiVMyVxWs8dDZ0NWvYTI8uToa8e7hBB6UVDV3SrtElyII7XMdglA-oONgXBkzXXqkIL5A36sQXijhYnSSiBZK0yj0lX1M3sBGtajiNjCTRJn4kGVF4VQQwlEtAZnk2sgyVyEfwOceMHvT1sewfeDYL0vwWoLXHhiL8A4g7TG1f0nZogL_57htFIB1M1R8dvJdUlm8hj1l2QA-9lKxeDJopKviYrUk30YmSuYiHcDbVlwPSyTHK0Gq8-4_F_QBno2uxmf27PT823t4Ti28CXPZgY36dhV3kanUfq_Zife-1eFQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hedgehog+partial+agonism+drives+Warburg-like+metabolism+in+muscle+and+brown+fat&rft.jtitle=Cell&rft.au=Teperino%2C+Raffaele&rft.au=Amann%2C+Sabine&rft.au=Bayer%2C+Martina&rft.au=McGee%2C+Sean+L&rft.date=2012-10-12&rft.eissn=1097-4172&rft.volume=151&rft.issue=2&rft.spage=414&rft_id=info:doi/10.1016%2Fj.cell.2012.09.021&rft_id=info%3Apmid%2F23063129&rft.externalDocID=23063129
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0092-8674&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0092-8674&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0092-8674&client=summon