EZH2 Expression in Head-and-Neck Squamous Cell Cancer in Young Patients

• Published in: International journal of molecular sciences Vol. 25; no. 10; p. 5250
• Main Authors: Révész, Mónika, Oberna, Ferenc, Slezák, András, Tóth, Erika, Ferenczi, Örs, Kenessey, István, Takácsi-Nagy, Zoltán
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Adult; Aged; Alcohol; Biomarkers, Tumor - metabolism; Cancer; Cell cycle; Enhancer of Zeste Homolog 2 Protein - genetics; Enhancer of Zeste Homolog 2 Protein - metabolism; Epigenetics; Female; Gene Expression Regulation, Neoplastic; Head & neck cancer; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Health aspects; Humans; Hypoxia; Larynx; Male; Medical prognosis; Metastasis; Middle Aged; Mortality; Patients; Prognosis; Regression analysis; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - pathology; Tumor Suppressor Protein p53 - metabolism; Tumors; Hungary; prognostic factors; head-and-neck cancer; young adults; EZH2

EZH2 (Enhancer of zeste homolog 2) promotes tumor growth and survival through numerous mechanisms and is a promising target for novel therapeutic approaches. We aimed to characterize the expression of EZH2 in the tumors of young head-and-neck squamous cell cancer (HNSCC) patients in comparison with...