Antigenic diversity and cross-reactivity of avian influenza H5N1 viruses in Egypt between 2006 and 2011

• Published in: Journal of general virology Vol. 93; no. 12; pp. 2564 - 2574
• Main Authors: El-Shesheny, Rabeh, Kayali, Ghazi, Kandeil, Ahmed, Cai, Zhipeng, Barakat, Ahmed B., Ghanim, Hossam, Ali, Mohamed A.
• Format: Journal Article
• Language: English
• Published: Reading Society for General Microbiology 01.12.2012
• Subjects: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibodies, Viral; Antigenic Variation; Antigens, Viral - chemistry; Antigens, Viral - genetics; Biological and medical sciences; Cross Reactions; Egypt; Fundamental and applied biological sciences. Psychology; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Influenza A Virus, H5N1 Subtype - classification; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - immunology; Influenza A Virus, H5N1 Subtype - isolation & purification; Influenza in Birds - virology; Microbiology; Miscellaneous; Models, Molecular; Molecular Sequence Data; Phylogeny; Poultry - virology; Rats; Sequence Homology, Amino Acid; Virology; Egypt; Egypt, Arab Rep; Vietnam; ASW, Caribbean Sea, Greater Antilles, Puerto Rico; Virus; Orthomyxoviridae; Influenzavirus A; Avian influenzavirus; Cross reaction

Influenza epidemics are a major health concern worldwide. Highly pathogenic avian influenza (HPAI) H5N1 viruses in Egypt have been subject to rapid genetic and antigenic changes since the first outbreak in February 2006 and have been endemic in poultry in Egypt since 2008. In this study, 33 H5N1 vir...