Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 305; no. 6; pp. G439 - G452
• Main Authors: Messenger, Scott W, Thomas, Diana D H, Falkowski, Michelle A, Byrne, Jennifer A, Gorelick, Fred S, Groblewski, Guy E
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.09.2013
• Subjects: Acinar Cells - metabolism; Animals; Antigens; Cells; Cells, Cultured; Endosomes - metabolism; Exocytosis; Lysosomes - metabolism; Membranes; Mutation; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Pancreas; Pancreas - cytology; Phosphorylation; Protein Transport; Proteins; Rats; Rats, Sprague-Dawley; Secretory Pathway; Secretory Vesicles - metabolism; SNARE Proteins - genetics; SNARE Proteins - metabolism; Tumors; Vesicular Transport Proteins - metabolism; TPD52; minor-regulated pathway; constitutive-like pathway; endolysosomal secretion

Zymogen granule (ZG) formation in acinar cells involves zymogen cargo sorting from trans-Golgi into immature secretory granules (ISGs). ISG maturation progresses by removal of lysosomal membrane and select content proteins, which enter endosomal intermediates prior to their apical exocytosis. Consti...