Pseudo-Pelger–Huët anomaly and granulocytic dysplasia associated with human granulocytic anaplasmosis
Pseudo-Pelger–Huët anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or hematological malignancies including myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Dysplastic changes in granulocytes are typical ma...
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| Published in | International journal of hematology Vol. 102; no. 1; pp. 129 - 133 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
Springer Japan
01.07.2015
Springer Nature B.V |
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| Abstract | Pseudo-Pelger–Huët anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or hematological malignancies including myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Dysplastic changes in granulocytes are typical manifestations in MDS and granulocytic leukemias. Here, we report the unique case of a patient found to have human granulocytic anaplasmosis (HGA), a tick-borne disease caused by
Anaplasma phagocytophilum
, a Gram-negative coccobacillus. This patient showed striking hematological manifestations including a large number of pseudo-PHA, a severe degree of left shift, and dysplastic granulocytes. These hematological presentations on the peripheral smear all resolved with doxycycline treatment, implying that the changes were most likely reactive manifestations secondary to HGA, rather than underlying hematological malignancies such as MDS or AML. |
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| AbstractList | Pseudo-Pelger–Huët anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or hematological malignancies including myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Dysplastic changes in granulocytes are typical manifestations in MDS and granulocytic leukemias. Here, we report the unique case of a patient found to have human granulocytic anaplasmosis (HGA), a tick-borne disease caused by
Anaplasma phagocytophilum
, a Gram-negative coccobacillus. This patient showed striking hematological manifestations including a large number of pseudo-PHA, a severe degree of left shift, and dysplastic granulocytes. These hematological presentations on the peripheral smear all resolved with doxycycline treatment, implying that the changes were most likely reactive manifestations secondary to HGA, rather than underlying hematological malignancies such as MDS or AML. Pseudo-Pelger–Huët anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or hematological malignancies including myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Dysplastic changes in granulocytes are typical manifestations in MDS and granulocytic leukemias. Here, we report the unique case of a patient found to have human granulocytic anaplasmosis (HGA), a tick-borne disease caused by Anaplasma phagocytophilum, a Gram-negative coccobacillus. This patient showed striking hematological manifestations including a large number of pseudo-PHA, a severe degree of left shift, and dysplastic granulocytes. These hematological presentations on the peripheral smear all resolved with doxycycline treatment, implying that the changes were most likely reactive manifestations secondary to HGA, rather than underlying hematological malignancies such as MDS or AML. |
| Author | Salama, Carlos Lieber, Joseph Lee, Sunyoung Khankhanian, Pouya Brown, Maritza |
| Author_xml | – sequence: 1 givenname: Sunyoung surname: Lee fullname: Lee, Sunyoung email: syandsy@gmail.com, sunyoung.s.lee@mssm.edu organization: Department of Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai – sequence: 2 givenname: Pouya surname: Khankhanian fullname: Khankhanian, Pouya organization: Department of Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai – sequence: 3 givenname: Carlos surname: Salama fullname: Salama, Carlos organization: Department of Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai – sequence: 4 givenname: Maritza surname: Brown fullname: Brown, Maritza organization: Department of Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai – sequence: 5 givenname: Joseph surname: Lieber fullname: Lieber, Joseph organization: Department of Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25749661$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jpeds_2016_02_065 crossref_primary_10_1172_jci_insight_148435 crossref_primary_10_3389_fimmu_2022_1076724 crossref_primary_10_3390_microorganisms10071433 |
| Cites_doi | 10.1002/ajh.10359 10.1136/vr.135.15.362 10.1182/blood-2012-07-445817 10.1016/j.cca.2010.07.011 10.1086/319350 10.1309/AJCP3G8MDUXYSCID 10.2460/javma.2003.223.1750 10.1016/S0002-9440(10)64145-4 10.1182/blood-2003-11-3850 10.1046/j.1365-2141.2003.04621.x 10.1111/j.1365-2141.1986.tb07550.x 10.1016/S0165-4608(96)00088-X 10.1100/2012/605743 10.1097/01.moh.0000190109.00532.56 10.1101/gad.1652708 10.1080/0031302022013136 10.1001/jama.1994.03520030054028 10.1016/j.idc.2008.03.011 10.1002/ajh.21320 10.1016/j.leukres.2007.04.012 10.1038/43591 10.1093/ajcp/87.1.66 10.1182/blood.V91.3.1008 10.4269/ajtmh.2000.62.29 10.1038/ng925 |
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| Keywords | Pseudo-Pelger–Huët anomaly Human granulocytic anaplasmosis Dysplastic granulocytes Tick-borne disease |
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| References | Bakken, Aguero-Rosenfeld, Tilden (CR18) 2001; 32 Dusse, Moreira, Vieira (CR11) 2010; 411 Cunningham, Patnaik, Hammerschmidt, Vercellotti (CR1) 2009; 84 Fradera (CR25) 2008; 112 Best, Salvati, Kallo (CR4) 2003; 123 Carlyon, Fikrig (CR14) 2006; 13 Bakken, Dumler (CR15) 2008; 22 Martin, Caspersen, Dumler (CR20) 2001; 158 Lepidi, Bunnell, Martin (CR19) 2000; 62 Kennedy, Kay, Johnson (CR10) 2002; 34 Hoffmann, Dreger, Olins (CR3) 2002; 31 McQuiston, McCall, Nicholson (CR13) 2003; 223 Bakken, Dumler, Chen (CR12) 1994; 272 Zamzami, Kroemer (CR26) 1999; 401 Kuriyama, Tomonaga, Matsuo (CR7) 1986; 63 Cadman, Kelly, Matthewman (CR16) 1994; 135 Soenen, Preudhomme, Roumier (CR6) 1998; 91 Dechat, Pfleghaar, Sengupta (CR2) 2008; 22 Fugazza, Bruzzone, Puppo, Sessarego (CR8) 1996; 90 Asmis, Hadaya, Majno (CR9) 2003; 73 Economopoulou, Pappa, Kontsioti (CR5) 2008; 32 Pozdnyakova, Dorfman (CR21) 2012; 120 Klion, Law, Riemenschneider (CR23) 2004; 103 Colella, Hollensead (CR22) 2012; 137 Rotondano, de Almeida, Lustosa (CR17) 2012; 2012 Weil, Hrisinko (CR24) 1987; 87 18381888 - Genes Dev. 2008 Apr 1;22(7):832-53 12879427 - Am J Hematol. 2003 Aug;73(4):244-8 14988154 - Blood. 2004 Jun 1;103(11):4050-5 11247709 - Clin Infect Dis. 2001 Mar 15;32(6):862-70 7846828 - Vet Rec. 1994 Oct 8;135(15):362 8830728 - Cancer Genet Cytogenet. 1996 Sep;90(2):166-70 14617022 - Br J Haematol. 2003 Nov;123(3):542-4 9446663 - Blood. 1998 Feb 1;91(3):1008-15 3460627 - Br J Haematol. 1986 Aug;63(4):665-9 16319684 - Curr Opin Hematol. 2006 Jan;13(1):28-33 12118250 - Nat Genet. 2002 Aug;31(4):410-4 20691170 - Clin Chim Acta. 2010 Nov 11;411(21-22):1587-90 22338047 - Am J Clin Pathol. 2012 Mar;137(3):358-66 18755383 - Infect Dis Clin North Am. 2008 Sep;22(3):433-48, viii 18672500 - Blood. 2008 Aug 1;112(3):479 11337387 - Am J Pathol. 2001 May;158(5):1881-8 19021122 - Am J Hematol. 2009 Feb;84(2):116-9 14690204 - J Am Vet Med Assoc. 2003 Dec 15;223(12):1750-6 23367517 - Blood. 2012 Dec 13;120(25):4911 10490018 - Nature. 1999 Sep 9;401(6749):127-8 2432775 - Am J Clin Pathol. 1987 Jan;87(1):66-70 12109788 - Pathology. 2002 Jun;34(3):263-6 22973174 - ScientificWorldJournal. 2012;2012:605743 10761721 - Am J Trop Med Hyg. 2000 Jan;62(1):29-37 17597205 - Leuk Res. 2008 Jan;32(1):61-9 8022040 - JAMA. 1994 Jul 20;272(3):212-8 V Soenen (1769_CR6) 1998; 91 C Economopoulou (1769_CR5) 2008; 32 JS Bakken (1769_CR15) 2008; 22 K Kuriyama (1769_CR7) 1986; 63 SC Weil (1769_CR24) 1987; 87 S Best (1769_CR4) 2003; 123 J Fradera (1769_CR25) 2008; 112 JS Bakken (1769_CR12) 1994; 272 TE Rotondano (1769_CR17) 2012; 2012 JA Carlyon (1769_CR14) 2006; 13 N Zamzami (1769_CR26) 1999; 401 H Lepidi (1769_CR19) 2000; 62 G Fugazza (1769_CR8) 1996; 90 LM Asmis (1769_CR9) 2003; 73 AD Klion (1769_CR23) 2004; 103 ME Martin (1769_CR20) 2001; 158 JM Cunningham (1769_CR1) 2009; 84 T Dechat (1769_CR2) 2008; 22 O Pozdnyakova (1769_CR21) 2012; 120 K Hoffmann (1769_CR3) 2002; 31 R Colella (1769_CR22) 2012; 137 GA Kennedy (1769_CR10) 2002; 34 HF Cadman (1769_CR16) 1994; 135 LM Dusse (1769_CR11) 2010; 411 JH McQuiston (1769_CR13) 2003; 223 JS Bakken (1769_CR18) 2001; 32 |
| References_xml | – volume: 73 start-page: 244 year: 2003 end-page: 248 ident: CR9 article-title: Acquired and reversible Pelger–Huët anomaly of polymorphonuclear neutrophils in three transplant patients receiving mycophenolate mofetil therapy publication-title: Am J Hematol doi: 10.1002/ajh.10359 contributor: fullname: Majno – volume: 135 start-page: 362 year: 1994 ident: CR16 article-title: Comparison of the dot-blot enzyme linked immunoassay with immunofluorescence for detecting antibodies to Ehrlichia canis publication-title: Vet Rec doi: 10.1136/vr.135.15.362 contributor: fullname: Matthewman – volume: 120 start-page: 4911 year: 2012 ident: CR21 article-title: Human granulocytic anaplasmosis publication-title: Blood doi: 10.1182/blood-2012-07-445817 contributor: fullname: Dorfman – volume: 411 start-page: 1587 year: 2010 end-page: 1590 ident: CR11 article-title: Acquired Pelger–Huët: what does it really mean publication-title: Clin Chim Acta doi: 10.1016/j.cca.2010.07.011 contributor: fullname: Vieira – volume: 91 start-page: 1008 year: 1998 end-page: 1015 ident: CR6 article-title: 17p Deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ publication-title: Blood contributor: fullname: Roumier – volume: 62 start-page: 29 year: 2000 end-page: 37 ident: CR19 article-title: Comparative pathology, and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections publication-title: Am J Trop Med Hyg contributor: fullname: Martin – volume: 32 start-page: 862 year: 2001 end-page: 870 ident: CR18 article-title: Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis publication-title: Clin Infect Dis doi: 10.1086/319350 contributor: fullname: Tilden – volume: 137 start-page: 358 year: 2012 end-page: 366 ident: CR22 article-title: Understanding and recognizing the Pelger–Huët anomaly publication-title: Am J Clin Pathol doi: 10.1309/AJCP3G8MDUXYSCID contributor: fullname: Hollensead – volume: 223 start-page: 1750 year: 2003 end-page: 1756 ident: CR13 article-title: Ehrlichiosis and related infections publication-title: J Am Vet Med Assoc doi: 10.2460/javma.2003.223.1750 contributor: fullname: Nicholson – volume: 158 start-page: 1881 year: 2001 end-page: 1888 ident: CR20 article-title: Immunopathology and ehrlichial propagation are regulated by interferon-γ and interleukin-10 in a murine model of human granulocytic ehrlichiosis publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64145-4 contributor: fullname: Dumler – volume: 103 start-page: 4050 year: 2004 end-page: 4055 ident: CR23 article-title: Familial eosinophilia: a benign disorder publication-title: Blood doi: 10.1182/blood-2003-11-3850 contributor: fullname: Riemenschneider – volume: 123 start-page: 542 year: 2003 end-page: 544 ident: CR4 article-title: Lamin B-receptor mutations in Pelger–Huët anomaly publication-title: Br J Haematol doi: 10.1046/j.1365-2141.2003.04621.x contributor: fullname: Kallo – volume: 63 start-page: 665 year: 1986 end-page: 669 ident: CR7 article-title: Diagnostic significance of detecting pseudo-Pelger-Huet anomalies and micro-megakaryocytes in myelodysplastic syndrome publication-title: Br J Haematol doi: 10.1111/j.1365-2141.1986.tb07550.x contributor: fullname: Matsuo – volume: 90 start-page: 166 year: 1996 end-page: 170 ident: CR8 article-title: Granulocytes with segmented nucleus retain normal chromosomes 17 in Philadelphia chromosome-positive chronic myeloid leukemia with i(17q) and pseudo-Pelger anomaly: a case report studied with fluorescence in situ hybridization publication-title: Cancer Genet Cytolgenet. doi: 10.1016/S0165-4608(96)00088-X contributor: fullname: Sessarego – volume: 87 start-page: 66 year: 1987 end-page: 70 ident: CR24 article-title: A hybrid eosinophilic-basophilic granulocyte in chronic granulocytic leukemia publication-title: Am J Clin Pathol contributor: fullname: Hrisinko – volume: 112 start-page: 479 year: 2008 ident: CR25 article-title: Erythroid karyorrhexis in myelodysplasia: bone marrow aspirate publication-title: Blood contributor: fullname: Fradera – volume: 31 start-page: 410 year: 2002 end-page: 414 ident: CR3 article-title: Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger–Huet anomaly) publication-title: Nat Genet contributor: fullname: Olins – volume: 2012 start-page: 605743 year: 2012 ident: CR17 article-title: An assessment of whole blood and fractions by nested PCR as a DNA source for diagnosing canine ehrlichiosis and anaplasmosis publication-title: Sci World J doi: 10.1100/2012/605743 contributor: fullname: Lustosa – volume: 13 start-page: 28 year: 2006 end-page: 33 ident: CR14 article-title: Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum publication-title: Curr Opin Hematol doi: 10.1097/01.moh.0000190109.00532.56 contributor: fullname: Fikrig – volume: 22 start-page: 832 year: 2008 end-page: 853 ident: CR2 article-title: Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin publication-title: Genes Dev doi: 10.1101/gad.1652708 contributor: fullname: Sengupta – volume: 34 start-page: 263 year: 2002 end-page: 266 ident: CR10 article-title: Neutrophil dysplasia characterised by a pseudo-Pelger-Huet anomaly occurring with the use of mycophenolate mofetil and ganciclovir following renal transplantation: a report of five cases publication-title: Pathology doi: 10.1080/0031302022013136 contributor: fullname: Johnson – volume: 272 start-page: 212 year: 1994 end-page: 218 ident: CR12 article-title: Human granulocytic ehrlichiosis in the upper Midwest United States: a new species emerging publication-title: JAMA doi: 10.1001/jama.1994.03520030054028 contributor: fullname: Chen – volume: 22 start-page: 433 year: 2008 end-page: 448 ident: CR15 article-title: Human granulocytic anaplasmosis publication-title: Infect Dis Clin North Am doi: 10.1016/j.idc.2008.03.011 contributor: fullname: Dumler – volume: 84 start-page: 116 year: 2009 end-page: 119 ident: CR1 article-title: Historical perspective and clinical implications of the Pelger-Huet cell publication-title: Am J Hematol doi: 10.1002/ajh.21320 contributor: fullname: Vercellotti – volume: 32 start-page: 61 year: 2008 end-page: 69 ident: CR5 article-title: Analysis of apoptosis regulatory gene expression in the bone marrow (BM) of adult de novo myelodysplastic syndromes (MDS) publication-title: Leuk Res doi: 10.1016/j.leukres.2007.04.012 contributor: fullname: Kontsioti – volume: 401 start-page: 127 year: 1999 end-page: 128 ident: CR26 article-title: Condensed matter in cell death publication-title: Nature doi: 10.1038/43591 contributor: fullname: Kroemer – volume: 32 start-page: 862 year: 2001 ident: 1769_CR18 publication-title: Clin Infect Dis doi: 10.1086/319350 contributor: fullname: JS Bakken – volume: 87 start-page: 66 year: 1987 ident: 1769_CR24 publication-title: Am J Clin Pathol doi: 10.1093/ajcp/87.1.66 contributor: fullname: SC Weil – volume: 91 start-page: 1008 year: 1998 ident: 1769_CR6 publication-title: Blood doi: 10.1182/blood.V91.3.1008 contributor: fullname: V Soenen – volume: 63 start-page: 665 year: 1986 ident: 1769_CR7 publication-title: Br J Haematol doi: 10.1111/j.1365-2141.1986.tb07550.x contributor: fullname: K Kuriyama – volume: 103 start-page: 4050 year: 2004 ident: 1769_CR23 publication-title: Blood doi: 10.1182/blood-2003-11-3850 contributor: fullname: AD Klion – volume: 62 start-page: 29 year: 2000 ident: 1769_CR19 publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2000.62.29 contributor: fullname: H Lepidi – volume: 401 start-page: 127 year: 1999 ident: 1769_CR26 publication-title: Nature doi: 10.1038/43591 contributor: fullname: N Zamzami – volume: 135 start-page: 362 year: 1994 ident: 1769_CR16 publication-title: Vet Rec doi: 10.1136/vr.135.15.362 contributor: fullname: HF Cadman – volume: 411 start-page: 1587 year: 2010 ident: 1769_CR11 publication-title: Clin Chim Acta doi: 10.1016/j.cca.2010.07.011 contributor: fullname: LM Dusse – volume: 32 start-page: 61 year: 2008 ident: 1769_CR5 publication-title: Leuk Res doi: 10.1016/j.leukres.2007.04.012 contributor: fullname: C Economopoulou – volume: 73 start-page: 244 year: 2003 ident: 1769_CR9 publication-title: Am J Hematol doi: 10.1002/ajh.10359 contributor: fullname: LM Asmis – volume: 84 start-page: 116 year: 2009 ident: 1769_CR1 publication-title: Am J Hematol doi: 10.1002/ajh.21320 contributor: fullname: JM Cunningham – volume: 34 start-page: 263 year: 2002 ident: 1769_CR10 publication-title: Pathology doi: 10.1080/0031302022013136 contributor: fullname: GA Kennedy – volume: 22 start-page: 832 year: 2008 ident: 1769_CR2 publication-title: Genes Dev doi: 10.1101/gad.1652708 contributor: fullname: T Dechat – volume: 123 start-page: 542 year: 2003 ident: 1769_CR4 publication-title: Br J Haematol doi: 10.1046/j.1365-2141.2003.04621.x contributor: fullname: S Best – volume: 22 start-page: 433 year: 2008 ident: 1769_CR15 publication-title: Infect Dis Clin North Am doi: 10.1016/j.idc.2008.03.011 contributor: fullname: JS Bakken – volume: 90 start-page: 166 year: 1996 ident: 1769_CR8 publication-title: Cancer Genet Cytolgenet. doi: 10.1016/S0165-4608(96)00088-X contributor: fullname: G Fugazza – volume: 158 start-page: 1881 year: 2001 ident: 1769_CR20 publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64145-4 contributor: fullname: ME Martin – volume: 223 start-page: 1750 year: 2003 ident: 1769_CR13 publication-title: J Am Vet Med Assoc doi: 10.2460/javma.2003.223.1750 contributor: fullname: JH McQuiston – volume: 120 start-page: 4911 year: 2012 ident: 1769_CR21 publication-title: Blood doi: 10.1182/blood-2012-07-445817 contributor: fullname: O Pozdnyakova – volume: 137 start-page: 358 year: 2012 ident: 1769_CR22 publication-title: Am J Clin Pathol doi: 10.1309/AJCP3G8MDUXYSCID contributor: fullname: R Colella – volume: 13 start-page: 28 year: 2006 ident: 1769_CR14 publication-title: Curr Opin Hematol doi: 10.1097/01.moh.0000190109.00532.56 contributor: fullname: JA Carlyon – volume: 31 start-page: 410 year: 2002 ident: 1769_CR3 publication-title: Nat Genet doi: 10.1038/ng925 contributor: fullname: K Hoffmann – volume: 272 start-page: 212 year: 1994 ident: 1769_CR12 publication-title: JAMA doi: 10.1001/jama.1994.03520030054028 contributor: fullname: JS Bakken – volume: 2012 start-page: 605743 year: 2012 ident: 1769_CR17 publication-title: Sci World J doi: 10.1100/2012/605743 contributor: fullname: TE Rotondano – volume: 112 start-page: 479 year: 2008 ident: 1769_CR25 publication-title: Blood contributor: fullname: J Fradera |
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| Snippet | Pseudo-Pelger–Huët anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or... Pseudo-Pelger-Huët anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or... |
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| SubjectTerms | Acute myeloid leukemia Adult Anaplasma phagocytophilum Anaplasmosis Anaplasmosis - diagnosis Anaplasmosis - drug therapy Anaplasmosis - microbiology Case Report Diagnosis, Differential Doxycycline Dysplasia Granulocytes - pathology Hematology Humans Leukemia Leukocytes (granulocytic) Male Medicine Medicine & Public Health Myelodysplastic syndrome Myeloid leukemia Neutrophils - pathology Oncology Parasitic diseases Patients Pelger-Huet Anomaly - diagnosis Tick-borne diseases |
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| Title | Pseudo-Pelger–Huët anomaly and granulocytic dysplasia associated with human granulocytic anaplasmosis |
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