Immunological responses to a multi-peptide vaccine targeting cancer-testis antigens and VEGFRs in advanced pancreatic cancer patients

• Published in: Oncoimmunology Vol. 2; no. 11; p. e27010
• Main Authors: Okuyama, Ryuji, Aruga, Atsushi, Hatori, Takashi, Takeda, Kazuyoshi, Yamamoto, Masakazu
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.11.2013; Landes Bioscience
• Subjects: cancer-testis antigens; clinical trial; immunotherapy; multi-target vaccine; Original Research; pancreatic cancer; peptide; VEGFR; clinical trial; pancreatic cancer; peptide; cancer-testis antigens; immunotherapy; multi-target vaccine; VEGFR

The prognosis of patients with advanced pancreatic cancer is extremely poor and there are only a few standard treatments. Here, we report the results of a Phase I clinical trial to investigate the safety, immunostimulatory effects, and antineoplastic activity of a multi-target vaccine composed of fo...