Optimisation and validation of a HS-SPME–GC–IT/MS method for analysis of carbonyl volatile compounds as biomarkers in human urine: Application in a pilot study to discriminate individuals with smoking habits - Calejo, Isabel; Moreira, Nathalie; Araújo, Ana Margarida; Carvalho, Márcia; Bastos, Maria de Lourdes; de Pinho, Paula Guedes (Talanta (Oxford), 2016)
Keywords: Adult; aldehydes; Aldehydes - urine; automation; biomarkers; Biomarkers - urine; Carbonyl compounds; Central Composite Design (CCD); chemometrics; derivatization; Female; Gas Chromatography-Mass Spectrometry - standards; headspace analysis; HS-SPME–GC–IT/MS method; Humans; hydroxylamine; Hydroxylamines - urine; ketones; Ketones - urine; Male; mass spectrometry; metabolites; Middle Aged; molecular weight; Pilot Projects; polydimethylsiloxane; Smoking - urine; Smoking habits; solid phase microextraction; Solid Phase Microextraction - standards; temperature; urinalysis; Urinary biomarkers; urine; volatile compounds; Volatile Organic Compounds - urine; Young Adult; Central Composite Design (CCD); Carbonyl compounds; Urinary biomarkers; HS-SPME–GC–IT/MS method; Smoking habits